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iTools: a framework for classification, categorization and integration of computational biology resources.

The advancement of the computational biology field hinges on progress in three fundamental directions--the development of new computational algorithms, the availability of informatics resource management infrastructures and the capability of tools to interoperate and synergize. There is an explosion in algorithms and tools for computational biology, which makes it difficult for biologists to find, compare and integrate such resources. We describe a new infrastructure, iTools, for managing the query, traversal and comparison of diverse computational biology resources. Specifically, iTools stores information about three types of resources--data, software tools and web-services. The iTools design, implementation and resource meta-data content reflect the broad research, computational, applied and scientific expertise available at the seven National Centers for Biomedical Computing. iTools provides a system for classification, categorization and integration of different computational biology resources across space-and-time scales, biomedical problems, computational infrastructures and mathematical foundations. A large number of resources are already iTools-accessible to the community and this infrastructure is rapidly growing. iTools includes human and machine interfaces to its resource meta-data repository. Investigators or computer programs may utilize these interfaces to search, compare, expand, revise and mine meta-data descriptions of existent computational biology resources. We propose two ways to browse and display the iTools dynamic collection of resources. The first one is based on an ontology of computational biology resources, and the second one is derived from hyperbolic projections of manifolds or complex structures onto planar discs. iTools is an open source project both in terms of the source code development as well as its meta-data content. iTools employs a decentralized, portable, scalable and lightweight framework for long-term resource management. We demonstrate several applications of iTools as a framework for integrated bioinformatics. iTools and the complete details about its specifications, usage and interfaces are available at the iTools web page

Pubmed ID: 18509477


  • Dinov ID
  • Rubin D
  • Lorensen W
  • Dugan J
  • Ma J
  • Murphy S
  • Kirschner B
  • Bug W
  • Sherman M
  • Floratos A
  • Kennedy D
  • Jagadish HV
  • Schmidt J
  • Athey B
  • Califano A
  • Musen M
  • Altman R
  • Kikinis R
  • Kohane I
  • Delp S
  • Parker DS
  • Toga AW


PloS one

Publication Data

May 29, 2008

Associated Grants

  • Agency: NIGMS NIH HHS, Id: U54 GM072970
  • Agency: NHGRI NIH HHS, Id: U54 HG004028
  • Agency: NCI NIH HHS, Id: U54-CA121852
  • Agency: NIDA NIH HHS, Id: U54-DA021519
  • Agency: NIBIB NIH HHS, Id: U54-EB005149
  • Agency: NIGMS NIH HHS, Id: U54-GM072970
  • Agency: NHGRI NIH HHS, Id: U54-HG004028
  • Agency: NLM NIH HHS, Id: U54-LM008748
  • Agency: NCRR NIH HHS, Id: U54-RR021813

Mesh Terms

  • Computational Biology
  • Databases, Factual
  • Internet
  • Systems Integration