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Dissociating the role of the orbitofrontal cortex and the striatum in the computation of goal values and prediction errors.

To make sound economic decisions, the brain needs to compute several different value-related signals. These include goal values that measure the predicted reward that results from the outcome generated by each of the actions under consideration, decision values that measure the net value of taking the different actions, and prediction errors that measure deviations from individuals' previous reward expectations. We used functional magnetic resonance imaging and a novel decision-making paradigm to dissociate the neural basis of these three computations. Our results show that they are supported by different neural substrates: goal values are correlated with activity in the medial orbitofrontal cortex, decision values are correlated with activity in the central orbitofrontal cortex, and prediction errors are correlated with activity in the ventral striatum.

Pubmed ID: 18509023

Authors

  • Hare TA
  • O'Doherty J
  • Camerer CF
  • Schultz W
  • Rangel A

Journal

The Journal of neuroscience : the official journal of the Society for Neuroscience

Publication Data

May 28, 2008

Associated Grants

  • Agency: Wellcome Trust, Id: 095495

Mesh Terms

  • Adult
  • Brain Mapping
  • Corpus Striatum
  • Decision Making
  • Female
  • Goals
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging
  • Male
  • Mathematics
  • Oxygen
  • Prefrontal Cortex
  • Regression Analysis
  • Reward
  • Task Performance and Analysis