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Complexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous system.

Complexins (Cplxs) are key regulators of synaptic exocytosis, but whether they act as facilitators or inhibitors is currently being disputed controversially. We show that genetic deletion of all Cplxs expressed in the mouse brain causes a reduction in Ca(2+)-triggered and spontaneous neurotransmitter release at both excitatory and inhibitory synapses. Our results demonstrate that at mammalian central nervous system synapses, Cplxs facilitate neurotransmitter release and do not simply act as inhibitory clamps of the synaptic vesicle fusion machinery.

Pubmed ID: 18505837


  • Xue M
  • Stradomska A
  • Chen H
  • Brose N
  • Zhang W
  • Rosenmund C
  • Reim K


Proceedings of the National Academy of Sciences of the United States of America

Publication Data

June 3, 2008

Associated Grants

  • Agency: NINDS NIH HHS, Id: NS50655
  • Agency: NINDS NIH HHS, Id: R01 NS050655-05

Mesh Terms

  • Adaptor Proteins, Vesicular Transport
  • Animals
  • Brain
  • Calcium
  • Evoked Potentials
  • Exocytosis
  • Eye Proteins
  • Mice
  • Mice, Knockout
  • Nerve Tissue Proteins
  • Neuronal Plasticity
  • Neurons
  • Neurotransmitter Agents
  • Synapses
  • Synaptic Transmission
  • Synaptic Vesicles