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Saccharomyces cerevisiae Yta7 regulates histone gene expression.

The Saccharomyces cerevisiae Yta7 protein is a component of a nucleosome bound protein complex that maintains distinct transcriptional zones of chromatin. We previously found that one protein copurifying with Yta7 is the yFACT member Spt16. Epistasis analyses revealed a link between Yta7, Spt16, and other previously identified members of the histone regulatory pathway. In concurrence, Yta7 was found to regulate histone gene transcription in a cell-cycle-dependent manner. Association at the histone gene loci appeared to occur through binding of the bromodomain-like region of Yta7 with the N-terminal tail of histone H3. Our work suggests a mechanism in which Yta7 is localized to chromatin to establish regions of transcriptional silencing, and that one facet of this cellular mechanism is to modulate transcription of histone genes.

Pubmed ID: 18493054

Authors

  • Gradolatto A
  • Rogers RS
  • Lavender H
  • Taverna SD
  • Allis CD
  • Aitchison JD
  • Tackett AJ

Journal

Genetics

Publication Data

May 21, 2008

Associated Grants

  • Agency: NIGMS NIH HHS, Id: GM076547
  • Agency: NIGMS NIH HHS, Id: GM63959
  • Agency: NCRR NIH HHS, Id: P20RR015569
  • Agency: NCRR NIH HHS, Id: P20RR016460
  • Agency: NCRR NIH HHS, Id: RR022220

Mesh Terms

  • Chromatin Immunoprecipitation
  • Chromosomal Proteins, Non-Histone
  • DNA Primers
  • Epistasis, Genetic
  • Flow Cytometry
  • Gene Expression Regulation, Fungal
  • Histones
  • Mass Spectrometry
  • Saccharomyces cerevisiae
  • Saccharomyces cerevisiae Proteins