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Epigenetic control of rDNA loci in response to intracellular energy status.

Cell | May 16, 2008

http://www.ncbi.nlm.nih.gov/pubmed/18485871

Intracellular energy balance is important for cell survival. In eukaryotic cells, the most energy-consuming process is ribosome biosynthesis, which adapts to changes in intracellular energy status. However, the mechanism that links energy status and ribosome biosynthesis is largely unknown. Here, we describe eNoSC, a protein complex that senses energy status and controls rRNA transcription. eNoSC contains Nucleomethylin, which binds histone H3 dimethylated Lys9 in the rDNA locus, in a complex with SIRT1 and SUV39H1. Both SIRT1 and SUV39H1 are required for energy-dependent transcriptional repression, suggesting that a change in the NAD(+)/NADH ratio induced by reduction of energy status could activate SIRT1, leading to deacetylation of histone H3 and dimethylation at Lys9 by SUV39H1, thus establishing silent chromatin in the rDNA locus. Furthermore, eNoSC promotes restoration of energy balance by limiting rRNA transcription, thus protecting cells from energy deprivation-dependent apoptosis. These findings provide key insight into the mechanisms of energy homeostasis in cells.

Pubmed ID: 18485871 RIS Download

Mesh terms: Cell Death | Cell Line | Cell Nucleolus | DNA, Ribosomal | Energy Metabolism | Gene Silencing | Glucose | Histone-Lysine N-Methyltransferase | Histones | Humans | Methyltransferases | Models, Molecular | Molecular Sequence Data | Multiprotein Complexes | NAD | Nuclear Proteins | Protein Methyltransferases | Protein Structure, Tertiary | Repressor Proteins | Sirtuin 1 | Sirtuins | Transcription, Genetic

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