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A myocardial lineage derives from Tbx18 epicardial cells.

Understanding the origins and roles of cardiac progenitor cells is important for elucidating the pathogenesis of congenital and acquired heart diseases. Moreover, manipulation of cardiac myocyte progenitors has potential for cell-based repair strategies for various myocardial disorders. Here we report the identification in mouse of a previously unknown cardiac myocyte lineage that derives from the proepicardial organ. These progenitor cells, which express the T-box transcription factor Tbx18, migrate onto the outer cardiac surface to form the epicardium, and then make a substantial contribution to myocytes in the ventricular septum and the atrial and ventricular walls. Tbx18-expressing cardiac progenitors also give rise to cardiac fibroblasts and coronary smooth muscle cells. The pluripotency of Tbx18 proepicardial cells provides a theoretical framework for applying these progenitors to effect cardiac repair and regeneration.

Pubmed ID: 18480752

Authors

  • Cai CL
  • Martin JC
  • Sun Y
  • Cui L
  • Wang L
  • Ouyang K
  • Yang L
  • Bu L
  • Liang X
  • Zhang X
  • Stallcup WB
  • Denton CP
  • McCulloch A
  • Chen J
  • Evans SM

Journal

Nature

Publication Data

July 3, 2008

Associated Grants

  • Agency: NCRR NIH HHS, Id: P41 RR005351
  • Agency: NHLBI NIH HHS, Id: R01 HL093339
  • Agency: NHLBI NIH HHS, Id: T32 HL007444

Mesh Terms

  • Animals
  • Cell Differentiation
  • Cell Lineage
  • Gene Expression Regulation, Developmental
  • Heart
  • Lac Operon
  • Mice
  • Myocardium
  • Myocytes, Cardiac
  • Myocytes, Smooth Muscle
  • Pericardium
  • Stem Cells
  • T-Box Domain Proteins