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Prestin-based outer hair cell motility is necessary for mammalian cochlear amplification.

Neuron | May 8, 2008

http://www.ncbi.nlm.nih.gov/pubmed/18466744

It is a central tenet of cochlear neurobiology that mammalian ears rely on a local, mechanical amplification process for their high sensitivity and sharp frequency selectivity. While it is generally agreed that outer hair cells provide the amplification, two mechanisms have been proposed: stereociliary motility and somatic motility. The latter is driven by the motor protein prestin. Electrophysiological phenotyping of a prestin knockout mouse intimated that somatic motility is the amplifier. However, outer hair cells of knockout mice have significantly altered mechanical properties, making this mouse model unsatisfactory. Here, we study a mouse model without alteration to outer hair cell and organ of Corti mechanics or to mechanoelectric transduction, but with diminished prestin function. These animals have knockout-like behavior, demonstrating that prestin-based electromotility is required for cochlear amplification.

Pubmed ID: 18466744 RIS Download

Mesh terms: Action Potentials | Animals | Auditory Threshold | Cell Movement | Cilia | Hair Cells, Auditory, Outer | Hearing | Mammals | Mechanotransduction, Cellular | Mice | Mice, Knockout | Mice, Mutant Strains | Models, Animal | Molecular Motor Proteins

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Associated grants

  • Agency: NCI NIH HHS, Id: CA023944
  • Agency: NCI NIH HHS, Id: CA21765
  • Agency: NIDCD NIH HHS, Id: DC 004696
  • Agency: NIDCD NIH HHS, Id: DC00089
  • Agency: NIDCD NIH HHS, Id: DC006412
  • Agency: NIDCD NIH HHS, Id: DC06471
  • Agency: NCI NIH HHS, Id: P30 CA021765
  • Agency: NCI NIH HHS, Id: P30 CA021765-28
  • Agency: NIDCD NIH HHS, Id: R01 DC000089
  • Agency: NIDCD NIH HHS, Id: R01 DC000089-38
  • Agency: NIDCD NIH HHS, Id: R01 DC004696
  • Agency: NIDCD NIH HHS, Id: R01 DC004696-08
  • Agency: NIDCD NIH HHS, Id: R01 DC006412
  • Agency: NIDCD NIH HHS, Id: R01 DC006412-03
  • Agency: NIDCD NIH HHS, Id: R01 DC006471
  • Agency: NIDCD NIH HHS, Id: R01 DC006471-05
  • Agency: NCI NIH HHS, Id: R25 CA023944
  • Agency: NCI NIH HHS, Id: R25 CA023944-24
  • Agency: NCRR NIH HHS, Id: UL1 RR025741

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