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Prestin-based outer hair cell motility is necessary for mammalian cochlear amplification.

It is a central tenet of cochlear neurobiology that mammalian ears rely on a local, mechanical amplification process for their high sensitivity and sharp frequency selectivity. While it is generally agreed that outer hair cells provide the amplification, two mechanisms have been proposed: stereociliary motility and somatic motility. The latter is driven by the motor protein prestin. Electrophysiological phenotyping of a prestin knockout mouse intimated that somatic motility is the amplifier. However, outer hair cells of knockout mice have significantly altered mechanical properties, making this mouse model unsatisfactory. Here, we study a mouse model without alteration to outer hair cell and organ of Corti mechanics or to mechanoelectric transduction, but with diminished prestin function. These animals have knockout-like behavior, demonstrating that prestin-based electromotility is required for cochlear amplification.

Pubmed ID: 18466744

Authors

  • Dallos P
  • Wu X
  • Cheatham MA
  • Gao J
  • Zheng J
  • Anderson CT
  • Jia S
  • Wang X
  • Cheng WH
  • Sengupta S
  • He DZ
  • Zuo J

Journal

Neuron

Publication Data

May 8, 2008

Associated Grants

  • Agency: NCI NIH HHS, Id: CA023944
  • Agency: NCI NIH HHS, Id: CA21765
  • Agency: NIDCD NIH HHS, Id: DC 004696
  • Agency: NIDCD NIH HHS, Id: DC00089
  • Agency: NIDCD NIH HHS, Id: DC006412
  • Agency: NIDCD NIH HHS, Id: DC06471
  • Agency: NCI NIH HHS, Id: P30 CA021765
  • Agency: NCI NIH HHS, Id: P30 CA021765-28
  • Agency: NIDCD NIH HHS, Id: R01 DC000089
  • Agency: NIDCD NIH HHS, Id: R01 DC000089-38
  • Agency: NIDCD NIH HHS, Id: R01 DC004696
  • Agency: NIDCD NIH HHS, Id: R01 DC004696-08
  • Agency: NIDCD NIH HHS, Id: R01 DC006412
  • Agency: NIDCD NIH HHS, Id: R01 DC006412-03
  • Agency: NIDCD NIH HHS, Id: R01 DC006471
  • Agency: NIDCD NIH HHS, Id: R01 DC006471-05
  • Agency: NCI NIH HHS, Id: R25 CA023944
  • Agency: NCI NIH HHS, Id: R25 CA023944-24
  • Agency: NCRR NIH HHS, Id: UL1 RR025741

Mesh Terms

  • Action Potentials
  • Animals
  • Auditory Threshold
  • Cell Movement
  • Cilia
  • Hair Cells, Auditory, Outer
  • Hearing
  • Mammals
  • Mechanotransduction, Cellular
  • Mice
  • Mice, Knockout
  • Mice, Mutant Strains
  • Models, Animal
  • Molecular Motor Proteins