Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

The serine protease TMPRSS6 is required to sense iron deficiency.

Science (New York, N.Y.) | May 23, 2008

http://www.ncbi.nlm.nih.gov/pubmed/18451267

Hepcidin, a liver-derived protein that restricts enteric iron absorption, is the key regulator of body iron content. Several proteins induce expression of the hepcidin-encoding gene Hamp in response to infection or high levels of iron. However, mechanism(s) of Hamp suppression during iron depletion are poorly understood. We describe mask: a recessive, chemically induced mutant mouse phenotype, characterized by progressive loss of body (but not facial) hair and microcytic anemia. The mask phenotype results from reduced absorption of dietary iron caused by high levels of hepcidin and is due to a splicing defect in the transmembrane serine protease 6 gene Tmprss6. Overexpression of normal TMPRSS6 protein suppresses activation of the Hamp promoter, and the TMPRSS6 cytoplasmic domain mediates Hamp suppression via proximal promoter element(s). TMPRSS6 is an essential component of a pathway that detects iron deficiency and blocks Hamp transcription, permitting enhanced dietary iron absorption.

Pubmed ID: 18451267 RIS Download

Mesh terms: Anemia, Macrocytic | Animals | Antimicrobial Cationic Peptides | Cell Line, Tumor | Gene Expression Regulation | Hepcidins | Humans | Iron | Membrane Proteins | Mice | Mice, Mutant Strains | Mice, Transgenic | Models, Biological | Mutation | Phenotype | Promoter Regions, Genetic | Protein Structure, Tertiary | Serine Endopeptidases | Signal Transduction | Transfection

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: NIAID NIH HHS, Id: AI054523
  • Agency: NIDDK NIH HHS, Id: DK53505-09
  • Agency: NIDDK NIH HHS, Id: R01 DK053505-09
  • Agency: NIAID NIH HHS, Id: U54 AI054523
  • Agency: NIAID NIH HHS, Id: U54 AI054523-019005

Mouse Genome Informatics (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.