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Quantitative magnetic resonance image analysis of the cerebellum in macrocephalic and normocephalic children and adults with autism.

A detailed morphometric analysis of the cerebellum in autism with and without macrocephaly. Four subject groups (N = 65; male; IQs > or = 65; age 7 to 26 years) were studied with quantitative MRI; normocephalic and macrocephalic individuals with autism without mental retardation were compared to normocephalic and benign macrocephalic typically developing individuals. Total cerebellum volumes and surface areas of four lobular midsagittal groups were measured. Independent t-tests between autism and control subjects matched for head size revealed no significant differences. Multivariate analyses of variance were also performed, using the diagnostic group as the fixed factor, cerebellar measures as the dependent variables and total intracranial volume, total brain volume, age, verbal IQ, and performance IQ as covariates. No significant differences were found; however, a trend was noted in which macrocephalic individuals with autism consistently exhibited slightly smaller cerebellar volume or surface area when compared to individuals with benign macrocephaly. In autism, with and without macrocephaly, cerebellar structures were found to be proportional to head size and did not differ from typically developing subjects.

Pubmed ID: 18419839


  • Cleavinger HB
  • Bigler ED
  • Johnson JL
  • Lu J
  • McMahon W
  • Lainhart JE


Journal of the International Neuropsychological Society : JINS

Publication Data

May 18, 2008

Associated Grants

  • Agency: NIMH NIH HHS, Id: R01 MH080826
  • Agency: NICHD NIH HHS, Id: U19 HD035476
  • Agency: NICHD NIH HHS, Id: U19 HD35476

Mesh Terms

  • Acetylglucosamine
  • Adolescent
  • Adult
  • Autistic Disorder
  • Case-Control Studies
  • Cephalometry
  • Cerebellum
  • Child
  • Congenital Abnormalities
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Intelligence
  • Magnetic Resonance Imaging
  • Male
  • Multivariate Analysis
  • Reproducibility of Results
  • Retrospective Studies