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The genome of the model beetle and pest Tribolium castaneum.

Tribolium castaneum is a member of the most species-rich eukaryotic order, a powerful model organism for the study of generalized insect development, and an important pest of stored agricultural products. We describe its genome sequence here. This omnivorous beetle has evolved the ability to interact with a diverse chemical environment, as shown by large expansions in odorant and gustatory receptors, as well as P450 and other detoxification enzymes. Development in Tribolium is more representative of other insects than is Drosophila, a fact reflected in gene content and function. For example, Tribolium has retained more ancestral genes involved in cell-cell communication than Drosophila, some being expressed in the growth zone crucial for axial elongation in short-germ development. Systemic RNA interference in T. castaneum functions differently from that in Caenorhabditis elegans, but nevertheless offers similar power for the elucidation of gene function and identification of targets for selective insect control.

Pubmed ID: 18362917

Authors

  • Tribolium Genome Sequencing Consortium
  • Richards S
  • Gibbs RA
  • Weinstock GM
  • Brown SJ
  • Denell R
  • Beeman RW
  • Gibbs R
  • Beeman RW
  • Brown SJ
  • Bucher G
  • Friedrich M
  • Grimmelikhuijzen CJ
  • Klingler M
  • Lorenzen M
  • Richards S
  • Roth S
  • Schröder R
  • Tautz D
  • Zdobnov EM
  • Muzny D
  • Gibbs RA
  • Weinstock GM
  • Attaway T
  • Bell S
  • Buhay CJ
  • Chandrabose MN
  • Chavez D
  • Clerk-Blankenburg KP
  • Cree A
  • Dao M
  • Davis C
  • Chacko J
  • Dinh H
  • Dugan-Rocha S
  • Fowler G
  • Garner TT
  • Garnes J
  • Gnirke A
  • Hawes A
  • Hernandez J
  • Hines S
  • Holder M
  • Hume J
  • Jhangiani SN
  • Joshi V
  • Khan ZM
  • Jackson L
  • Kovar C
  • Kowis A
  • Lee S
  • Lewis LR
  • Margolis J
  • Morgan M
  • Nazareth LV
  • Nguyen N
  • Okwuonu G
  • Parker D
  • Richards S
  • Ruiz SJ
  • Santibanez J
  • Savard J
  • Scherer SE
  • Schneider B
  • Sodergren E
  • Tautz D
  • Vattahil S
  • Villasana D
  • White CS
  • Wright R
  • Park Y
  • Beeman RW
  • Lord J
  • Oppert B
  • Lorenzen M
  • Brown S
  • Wang L
  • Savard J
  • Tautz D
  • Richards S
  • Weinstock G
  • Gibbs RA
  • Liu Y
  • Worley K
  • Weinstock G
  • Elsik CG
  • Reese JT
  • Elhaik E
  • Landan G
  • Graur D
  • Arensburger P
  • Atkinson P
  • Beeman RW
  • Beidler J
  • Brown SJ
  • Demuth JP
  • Drury DW
  • Du YZ
  • Fujiwara H
  • Lorenzen M
  • Maselli V
  • Osanai M
  • Park Y
  • Robertson HM
  • Tu Z
  • Wang JJ
  • Wang S
  • Richards S
  • Song H
  • Zhang L
  • Sodergren E
  • Werner D
  • Stanke M
  • Morgenstern B
  • Solovyev V
  • Kosarev P
  • Brown G
  • Chen HC
  • Ermolaeva O
  • Hlavina W
  • Kapustin Y
  • Kiryutin B
  • Kitts P
  • Maglott D
  • Pruitt K
  • Sapojnikov V
  • Souvorov A
  • Mackey AJ
  • Waterhouse RM
  • Wyder S
  • Zdobnov EM
  • Zdobnov EM
  • Wyder S
  • Kriventseva EV
  • Kadowaki T
  • Bork P
  • Aranda M
  • Bao R
  • Beermann A
  • Berns N
  • Bolognesi R
  • Bonneton F
  • Bopp D
  • Brown SJ
  • Bucher G
  • Butts T
  • Chaumot A
  • Denell RE
  • Ferrier DE
  • Friedrich M
  • Gordon CM
  • Jindra M
  • Klingler M
  • Lan Q
  • Lattorff HM
  • Laudet V
  • von Levetsow C
  • Liu Z
  • Lutz R
  • Lynch JA
  • da Fonseca RN
  • Posnien N
  • Reuter R
  • Roth S
  • Savard J
  • Schinko JB
  • Schmitt C
  • Schoppmeier M
  • Schröder R
  • Shippy TD
  • Simonnet F
  • Marques-Souza H
  • Tautz D
  • Tomoyasu Y
  • Trauner J
  • Van der Zee M
  • Vervoort M
  • Wittkopp N
  • Wimmer EA
  • Yang X
  • Jones AK
  • Sattelle DB
  • Ebert PR
  • Nelson D
  • Scott JG
  • Beeman RW
  • Muthukrishnan S
  • Kramer KJ
  • Arakane Y
  • Beeman RW
  • Zhu Q
  • Hogenkamp D
  • Dixit R
  • Oppert B
  • Jiang H
  • Zou Z
  • Marshall J
  • Elpidina E
  • Vinokurov K
  • Oppert C
  • Zou Z
  • Evans J
  • Lu Z
  • Zhao P
  • Sumathipala N
  • Altincicek B
  • Vilcinskas A
  • Williams M
  • Hultmark D
  • Hetru C
  • Jiang H
  • Grimmelikhuijzen CJ
  • Hauser F
  • Cazzamali G
  • Williamson M
  • Park Y
  • Li B
  • Tanaka Y
  • Predel R
  • Neupert S
  • Schachtner J
  • Verleyen P
  • Raible F
  • Bork P
  • Friedrich M
  • Walden KK
  • Robertson HM
  • Angeli S
  • Forêt S
  • Bucher G
  • Schuetz S
  • Maleszka R
  • Wimmer EA
  • Beeman RW
  • Lorenzen M
  • Tomoyasu Y
  • Miller SC
  • Grossmann D
  • Bucher G

Journal

Nature

Publication Data

April 24, 2008

Associated Grants

  • Agency: Biotechnology and Biological Sciences Research Council, Id: BBS/B/12067
  • Agency: Biotechnology and Biological Sciences Research Council, Id: BBS/B/12067/2
  • Agency: NIGMS NIH HHS, Id: R01 GM058634
  • Agency: NICHD NIH HHS, Id: R01 HD029594
  • Agency: NICHD NIH HHS, Id: R01 HD029594-16
  • Agency: NHGRI NIH HHS, Id: U54 HG003273
  • Agency: Intramural NIH HHS, Id:

Mesh Terms

  • Animals
  • Base Composition
  • Body Patterning
  • Cytochrome P-450 Enzyme System
  • DNA Transposable Elements
  • Genes, Insect
  • Genome, Insect
  • Growth and Development
  • Humans
  • Insecticides
  • Neurotransmitter Agents
  • Oogenesis
  • Phylogeny
  • Proteome
  • RNA Interference
  • Receptors, G-Protein-Coupled
  • Receptors, Odorant
  • Repetitive Sequences, Nucleic Acid
  • Taste
  • Telomere
  • Tribolium
  • Vision, Ocular