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Redefining the serotonergic system by genetic lineage.

Central serotonin-producing neurons are heterogeneous-differing in location, morphology, neurotoxin sensitivity and associated clinical disorders-but the underpinnings of this heterogeneity are largely unknown, as are the markers that distinguish physiological subtypes of serotonergic neurons. Here we redefined serotonergic subtypes on the basis of genetic programs that are differentially enacted in progenitor cells. We uncovered a molecular framework for the serotonergic system that, having genetic lineages as its basis, is likely to have physiological relevance and will permit access to genetically defined subtypes for manipulation.

Pubmed ID: 18344997

Authors

  • Jensen P
  • Farago AF
  • Awatramani RB
  • Scott MM
  • Deneris ES
  • Dymecki SM

Journal

Nature neuroscience

Publication Data

April 27, 2008

Associated Grants

  • Agency: NICHD NIH HHS, Id: P01 HD036379
  • Agency: NICHD NIH HHS, Id: P01 HD036379
  • Agency: NICHD NIH HHS, Id: P01 HD036379-120007
  • Agency: NICHD NIH HHS, Id: P01 HD036379-130007
  • Agency: NIDDK NIH HHS, Id: R01 DK 067826
  • Agency: NIDDK NIH HHS, Id: R01 DK067826
  • Agency: NIDDK NIH HHS, Id: R01 DK067826-04
  • Agency: NIMH NIH HHS, Id: R01 MH62723
  • Agency: NIDA NIH HHS, Id: R21 DA023643
  • Agency: NIDA NIH HHS, Id: R21 DA023643
  • Agency: NIDA NIH HHS, Id: R21 DA023643-01
  • Agency: NIDA NIH HHS, Id: R21 DA023643-02

Mesh Terms

  • Animals
  • Biological Markers
  • Cell Differentiation
  • Cell Lineage
  • Gene Expression Profiling
  • Gene Expression Regulation, Developmental
  • Mice
  • Mice, Transgenic
  • Neurons
  • Rhombencephalon
  • Serotonin
  • Stem Cells
  • Transgenes