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Age-dependent tolerance to an endogenous tumor-associated antigen.

Immunologic tolerance to endogenous antigens reduces antitumor responses. Gp70 is an endogenous tumor-associated antigen (TAA) of the BALB/c-derived colon carcinoma CT26. We found that expression of gp70 mRNA is detectable in tissues of mice 8 months of age and older. We showed that expression of gp70 establishes immunologic tolerance and affects antitumor immunity in a similarly age-dependent manner using gp70-deficient mice. We found that tumors grew in all gp70-sufficient mice, while approximately half of gp70-deficient mice controlled tumor growth with endogenous T-cell responses. Protection in gp70-deficient mice correlated with more robust gp70-specific CTL responses, and increased numbers and avidity of responding antigen-specific T cells after vaccination. We conclude that immunosurveillance may decline with age due to increased or de novo peripheral expression of endogenous TAAs.

Pubmed ID: 18329760


  • McWilliams JA
  • Sullivan RT
  • Jordan KR
  • McMahan RH
  • Kemmler CB
  • McDuffie M
  • Slansky JE



Publication Data

March 28, 2008

Associated Grants

  • Agency: NCI NIH HHS, Id: CA109560
  • Agency: NCI NIH HHS, Id: R01 CA109560
  • Agency: NCI NIH HHS, Id: R01 CA109560-04

Mesh Terms

  • Aging
  • Animals
  • Antigens, Neoplasm
  • Colonic Neoplasms
  • Female
  • Immune Tolerance
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Knockout
  • T-Lymphocytes