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Age-dependent tolerance to an endogenous tumor-associated antigen.

Vaccine | Mar 28, 2008

http://www.ncbi.nlm.nih.gov/pubmed/18329760

Immunologic tolerance to endogenous antigens reduces antitumor responses. Gp70 is an endogenous tumor-associated antigen (TAA) of the BALB/c-derived colon carcinoma CT26. We found that expression of gp70 mRNA is detectable in tissues of mice 8 months of age and older. We showed that expression of gp70 establishes immunologic tolerance and affects antitumor immunity in a similarly age-dependent manner using gp70-deficient mice. We found that tumors grew in all gp70-sufficient mice, while approximately half of gp70-deficient mice controlled tumor growth with endogenous T-cell responses. Protection in gp70-deficient mice correlated with more robust gp70-specific CTL responses, and increased numbers and avidity of responding antigen-specific T cells after vaccination. We conclude that immunosurveillance may decline with age due to increased or de novo peripheral expression of endogenous TAAs.

Pubmed ID: 18329760 RIS Download

Mesh terms: Aging | Animals | Antigens, Neoplasm | Colonic Neoplasms | Female | Immune Tolerance | Male | Mice | Mice, Inbred BALB C | Mice, Inbred C57BL | Mice, Knockout | T-Lymphocytes

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Associated grants

  • Agency: NCI NIH HHS, Id: CA109560
  • Agency: NCI NIH HHS, Id: R01 CA109560
  • Agency: NCI NIH HHS, Id: R01 CA109560-04

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