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Constitutive expression of IL-7 receptor alpha does not support increased expansion or prevent contraction of antigen-specific CD4 or CD8 T cells following Listeria monocytogenes infection.

Expression of IL-7Ralpha (CD127) has been suggested as a major determinant in the survival of memory T cell precursors. We investigated whether constitutive expression of IL-7Ralpha on T cells increased expansion and/or decreased contraction of endogenous Ag-specific CD4 and CD8 T cells following infection with Listeria monocytogenes. The results indicate that constitutive expression of IL-7Ralpha alone was not enough to impart an expansion or survival advantage to CD8 T cells responding to infection, and did not increase memory CD8 T cell numbers over those observed in wild-type controls. Constitutive expression of IL-7Ralpha did allow for slightly prolonged expansion of Ag-specific CD4 T cells; however, it did not alter the contraction phase or protect against the waning of memory T cell numbers at later times after infection. Memory CD4 and CD8 T cells generated in IL-7Ralpha transgenic mice expanded similarly to wild-type T cells after secondary infection, and immunized IL-7Ralpha transgenic mice were fully protected against lethal bacterial challenge demonstrating that constitutive expression of IL-7Ralpha does not impair, or markedly improve memory/secondary effector T cell function. These results indicate that expression of IL-7Ralpha alone does not support increased survival of effector Ag-specific CD4 or CD8 T cells into the memory phase following bacterial infection.

Pubmed ID: 18292507

Authors

  • Haring JS
  • Jing X
  • Bollenbacher-Reilley J
  • Xue HH
  • Leonard WJ
  • Harty JT

Journal

Journal of immunology (Baltimore, Md. : 1950)

Publication Data

March 1, 2008

Associated Grants

  • Agency: NIAID NIH HHS, Id: AI42767
  • Agency: NIAID NIH HHS, Id: AI46653
  • Agency: NIAID NIH HHS, Id: AI50073

Mesh Terms

  • Animals
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Cell Death
  • Cell Proliferation
  • Cell Survival
  • Epitopes, T-Lymphocyte
  • Growth Inhibitors
  • Immunologic Memory
  • Listeria monocytogenes
  • Listeriosis
  • Lymphocyte Activation
  • Lymphocyte Count
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Receptors, Interleukin-7