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Spine-type-specific recruitment of newly synthesized AMPA receptors with learning.

Science (New York, N.Y.) | Feb 22, 2008

http://www.ncbi.nlm.nih.gov/pubmed/18292343

The stabilization of long-term memories requires de novo protein synthesis. How can proteins, synthesized in the soma, act on specific synapses that participate in a given memory? We studied the dynamics of newly synthesized AMPA-type glutamate receptors (AMPARs) induced with learning using transgenic mice expressing the GluR1 subunit fused to green fluorescent protein (GFP-GluR1) under control of the c-fos promoter. We found learning-associated recruitment of newly synthesized GFP-GluR1 selectively to mushroom-type spines in adult hippocampal CA1 neurons 24 hours after fear conditioning. Our results are consistent with a "synaptic tagging" model to allow activated synapses to subsequently capture newly synthesized receptor and also demonstrate a critical functional distinction in the mushroom spines with learning.

Pubmed ID: 18292343 RIS Download

Mesh terms: Animals | Conditioning (Psychology) | Dendritic Spines | Doxycycline | Extinction, Psychological | Fear | Hippocampus | Learning | Long-Term Potentiation | Male | Memory | Mice | Mice, Transgenic | Protein Transport | Pyramidal Cells | Receptors, AMPA | Recombinant Fusion Proteins | Synapses

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Associated grants

  • Agency: NIMH NIH HHS, Id: MH070020
  • Agency: NIMH NIH HHS, Id: MH57368
  • Agency: NIMH NIH HHS, Id: R01 MH057368
  • Agency: NIMH NIH HHS, Id: R01 MH057368-03
  • Agency: NIMH NIH HHS, Id: R01 MH057368-04
  • Agency: NIMH NIH HHS, Id: R21 MH070020
  • Agency: NIMH NIH HHS, Id: R21 MH070020-01
  • Agency: NIMH NIH HHS, Id: R21 MH070020-02
  • Agency: NIMH NIH HHS, Id: R21 MH070020-03

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