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Spine-type-specific recruitment of newly synthesized AMPA receptors with learning.

The stabilization of long-term memories requires de novo protein synthesis. How can proteins, synthesized in the soma, act on specific synapses that participate in a given memory? We studied the dynamics of newly synthesized AMPA-type glutamate receptors (AMPARs) induced with learning using transgenic mice expressing the GluR1 subunit fused to green fluorescent protein (GFP-GluR1) under control of the c-fos promoter. We found learning-associated recruitment of newly synthesized GFP-GluR1 selectively to mushroom-type spines in adult hippocampal CA1 neurons 24 hours after fear conditioning. Our results are consistent with a "synaptic tagging" model to allow activated synapses to subsequently capture newly synthesized receptor and also demonstrate a critical functional distinction in the mushroom spines with learning.

Pubmed ID: 18292343

Authors

  • Matsuo N
  • Reijmers L
  • Mayford M

Journal

Science (New York, N.Y.)

Publication Data

February 22, 2008

Associated Grants

  • Agency: NIMH NIH HHS, Id: MH070020
  • Agency: NIMH NIH HHS, Id: MH57368
  • Agency: NIMH NIH HHS, Id: R01 MH057368
  • Agency: NIMH NIH HHS, Id: R01 MH057368-03
  • Agency: NIMH NIH HHS, Id: R01 MH057368-04
  • Agency: NIMH NIH HHS, Id: R21 MH070020
  • Agency: NIMH NIH HHS, Id: R21 MH070020-01
  • Agency: NIMH NIH HHS, Id: R21 MH070020-02
  • Agency: NIMH NIH HHS, Id: R21 MH070020-03

Mesh Terms

  • Animals
  • Conditioning (Psychology)
  • Dendritic Spines
  • Doxycycline
  • Extinction, Psychological
  • Fear
  • Hippocampus
  • Learning
  • Long-Term Potentiation
  • Male
  • Memory
  • Mice
  • Mice, Transgenic
  • Protein Transport
  • Pyramidal Cells
  • Receptors, AMPA
  • Recombinant Fusion Proteins
  • Synapses