• Register
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.


Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.


Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens.

Infections by attaching and effacing (A/E) bacterial pathogens, such as Escherichia coli O157:H7, pose a serious threat to public health. Using a mouse A/E pathogen, Citrobacter rodentium, we show that interleukin-22 (IL-22) has a crucial role in the early phase of host defense against C. rodentium. Infection of IL-22 knockout mice results in increased intestinal epithelial damage, systemic bacterial burden and mortality. We also find that IL-23 is required for the early induction of IL-22 during C. rodentium infection, and adaptive immunity is not essential for the protective role of IL-22 in this model. Instead, IL-22 is required for the direct induction of the Reg family of antimicrobial proteins, including RegIIIbeta and RegIIIgamma, in colonic epithelial cells. Exogenous mouse or human RegIIIgamma substantially improves survival of IL-22 knockout mice after C. rodentium infection. Together, our data identify a new innate immune function for IL-22 in regulating early defense mechanisms against A/E bacterial pathogens.

Pubmed ID: 18264109


  • Zheng Y
  • Valdez PA
  • Danilenko DM
  • Hu Y
  • Sa SM
  • Gong Q
  • Abbas AR
  • Modrusan Z
  • Ghilardi N
  • de Sauvage FJ
  • Ouyang W


Nature medicine

Publication Data

March 7, 2008

Associated Grants


Mesh Terms

  • Animals
  • Bacterial Adhesion
  • Citrobacter rodentium
  • Colon
  • Cysteine Endopeptidases
  • Enterobacteriaceae Infections
  • Gene Expression Regulation
  • Immunity, Innate
  • Interleukin-23
  • Interleukins
  • Intestinal Mucosa
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Time Factors