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Direct evidence for epithelial-mesenchymal transitions in breast cancer.

We developed stromal- and epithelial-specific cre-transgenic mice to directly visualize epithelial-mesenchymal transition (EMT) during cancer progression in vivo. Using three different oncogene-driven mouse mammary tumor models and cell-fate mapping strategies, we show in vivo evidence for the existence of EMT in breast cancer and show that myc can specifically elicit this process. Hierarchical cluster analysis of genome-wide loss of heterozygosity reveals that the incidence of EMT in invasive human breast carcinomas is rare, but when it occurs it is associated with the amplification of MYC. These data provide the first direct evidence for EMT in breast cancer and suggest that its development is favored by myc-initiated events.

Pubmed ID: 18245497

Authors

  • Trimboli AJ
  • Fukino K
  • de Bruin A
  • Wei G
  • Shen L
  • Tanner SM
  • Creasap N
  • Rosol TJ
  • Robinson ML
  • Eng C
  • Ostrowski MC
  • Leone G

Journal

Cancer research

Publication Data

February 1, 2008

Associated Grants

  • Agency: NCI NIH HHS, Id: P01 CA097189
  • Agency: NCI NIH HHS, Id: R01 CA053271

Mesh Terms

  • Animals
  • Breast Neoplasms
  • Epithelial Cells
  • Female
  • Genes, myc
  • Humans
  • Loss of Heterozygosity
  • Mammary Neoplasms, Experimental
  • Mesoderm
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Neoplasm Invasiveness
  • Pregnancy