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Common neural substrates for inhibition of spoken and manual responses.

The inhibition of speech acts is a critical aspect of human executive control over thought and action, but its neural underpinnings are poorly understood. Using functional magnetic resonance imaging and the stop-signal paradigm, we examined the neural correlates of speech control in comparison to manual motor control. Initiation of a verbal response activated left inferior frontal cortex (IFC: Broca's area). Successful inhibition of speech (naming of letters or pseudowords) engaged a region of right IFC (including pars opercularis and anterior insular cortex) as well as presupplementary motor area (pre-SMA); these regions were also activated by successful inhibition of a hand response (i.e., a button press). Moreover, the speed with which subjects inhibited their responses, stop-signal reaction time, was significantly correlated between speech and manual inhibition tasks. These findings suggest a functional dissociation of left and right IFC in initiating versus inhibiting vocal responses, and that manual responses and speech acts share a common inhibitory mechanism localized in the right IFC and pre-SMA.

Pubmed ID: 18245044


  • Xue G
  • Aron AR
  • Poldrack RA


Cerebral cortex (New York, N.Y. : 1991)

Publication Data

August 17, 2008

Associated Grants


Mesh Terms

  • Adolescent
  • Adult
  • Brain Mapping
  • Cerebral Cortex
  • Female
  • Humans
  • Inhibition (Psychology)
  • Male
  • Motor Skills
  • Psychomotor Performance
  • Reaction Time
  • Speech