• Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

Common neural substrates for inhibition of spoken and manual responses.

The inhibition of speech acts is a critical aspect of human executive control over thought and action, but its neural underpinnings are poorly understood. Using functional magnetic resonance imaging and the stop-signal paradigm, we examined the neural correlates of speech control in comparison to manual motor control. Initiation of a verbal response activated left inferior frontal cortex (IFC: Broca's area). Successful inhibition of speech (naming of letters or pseudowords) engaged a region of right IFC (including pars opercularis and anterior insular cortex) as well as presupplementary motor area (pre-SMA); these regions were also activated by successful inhibition of a hand response (i.e., a button press). Moreover, the speed with which subjects inhibited their responses, stop-signal reaction time, was significantly correlated between speech and manual inhibition tasks. These findings suggest a functional dissociation of left and right IFC in initiating versus inhibiting vocal responses, and that manual responses and speech acts share a common inhibitory mechanism localized in the right IFC and pre-SMA.

Pubmed ID: 18245044

Authors

  • Xue G
  • Aron AR
  • Poldrack RA

Journal

Cerebral cortex (New York, N.Y. : 1991)

Publication Data

August 17, 2008

Associated Grants

None

Mesh Terms

  • Adolescent
  • Adult
  • Brain Mapping
  • Cerebral Cortex
  • Female
  • Humans
  • Inhibition (Psychology)
  • Male
  • Motor Skills
  • Psychomotor Performance
  • Reaction Time
  • Speech