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Myo2p, a class V myosin in budding yeast, associates with a large ribonucleic acid-protein complex that contains mRNAs and subunits of the RNA-processing body.

RNA (New York, N.Y.) | Mar 26, 2008

Myo2p is an essential class V myosin in budding yeast with several identified functions in organelle trafficking and spindle orientation. The present study demonstrates that Myo2p is a component of a large RNA-containing complex (Myo2p-RNP) that is distinct from polysomes based on sedimentation analysis and lack of ribosomal subunits in the Myo2p-RNP. Microarray analysis of RNAs that coimmunoprecipitate with Myo2p revealed the presence of a large number of mRNAs in this complex. The Myo2p-RNA complex is in part composed of the RNA processing body (P-body) based on coprecipitation with P-body protein subunits and partial colocalization of Myo2p with P-bodies. P-body disassembly is delayed in the motor mutant, myo2-66, indicating that Myo2p may facilitate the release of mRNAs from the P-body.

Pubmed ID: 18218704 RIS Download

Mesh terms: Actins | Adenosine Triphosphatases | Base Sequence | DNA Primers | Macromolecular Substances | Myosin Heavy Chains | Myosin Type V | Oligonucleotide Array Sequence Analysis | Organelles | Polyribosomes | RNA Processing, Post-Transcriptional | RNA, Fungal | RNA, Messenger | Ribonucleoproteins | Saccharomyces cerevisiae | Saccharomyces cerevisiae Proteins | Secretory Vesicles | Vacuoles

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Associated grants

  • Agency: NIGMS NIH HHS, Id: GM073823
  • Agency: NIGMS NIH HHS, Id: R01 GM073823
  • Agency: NIDDK NIH HHS, Id: P01 DK055389
  • Agency: NIGMS NIH HHS, Id: R01 GM057071
  • Agency: NIGMS NIH HHS, Id: GM57071
  • Agency: NIDDK NIH HHS, Id: R01 DK025387
  • Agency: NIDDK NIH HHS, Id: P0-1-DK-55389
  • Agency: NIDDK NIH HHS, Id: R0-1 DK-25387

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