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Thalamic filtering of retinal spike trains by postsynaptic summation.

Journal of vision | Dec 28, 2007

At many synapses in the central nervous system, spikes within high-frequency trains have a better chance of driving the postsynaptic neuron than spikes occurring in isolation. We asked what mechanism accounts for this selectivity at the retinogeniculate synapse. The amplitude of synaptic potentials was remarkably constant, ruling out a major role for presynaptic mechanisms such as synaptic facilitation. Instead, geniculate spike trains could be predicted from retinal spike trains on the basis of postsynaptic summation. This simple form of integration explains the response differences between a geniculate neuron and its main retinal driver, and thereby determines the flow of visual information to cortex.

Pubmed ID: 18217815 RIS Download

Mesh terms: Action Potentials | Animals | Geniculate Bodies | Macaca | Models, Neurological | Reaction Time | Retinal Ganglion Cells | Synapses

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Associated grants

  • Agency: NEI NIH HHS, Id: R01-EY10217
  • Agency: NCRR NIH HHS, Id: RR00169
  • Agency: NCRR NIH HHS, Id: P51 RR000169
  • Agency: NEI NIH HHS, Id: R01-EY017396
  • Agency: NEI NIH HHS, Id: R01 EY017396
  • Agency: NEI NIH HHS, Id: R01 EY010217
  • Agency: NEI NIH HHS, Id: R01 EY017396-01
  • Agency: NEI NIH HHS, Id: P30 EY002162

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