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Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF.

Nature neuroscience | Feb 29, 2008

Pro- and mature BDNF activate very different receptors and intracellular pathways, potentially leading to either neuronal death or survival. Here we examined the biochemistry of endogenous BDNF in mouse neurons using sensitive reagents and found that pro-BDNF is rapidly converted intracellularly to mature BDNF, the latter being stored and released by excitatory input.

Pubmed ID: 18204444 RIS Download

Mesh terms: Animals | Brain-Derived Neurotrophic Factor | COS Cells | Cercopithecus aethiops | Dose-Response Relationship, Radiation | Electric Stimulation | Enzyme-Linked Immunosorbent Assay | Hippocampus | Immunoprecipitation | Long-Term Potentiation | Methionine | Mice | Mice, Knockout | Neurons | Patch-Clamp Techniques | Protein Precursors | Synaptic Transmission | Transfection | Tritium

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