Literature search services are currently unavailable. During our hosting provider's UPS upgrade we experienced a hardware failure and are currently working to resolve the issue.

Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF.

Pro- and mature BDNF activate very different receptors and intracellular pathways, potentially leading to either neuronal death or survival. Here we examined the biochemistry of endogenous BDNF in mouse neurons using sensitive reagents and found that pro-BDNF is rapidly converted intracellularly to mature BDNF, the latter being stored and released by excitatory input.

Pubmed ID: 18204444


  • Matsumoto T
  • Rauskolb S
  • Polack M
  • Klose J
  • Kolbeck R
  • Korte M
  • Barde YA


Nature neuroscience

Publication Data

February 29, 2008

Associated Grants


Mesh Terms

  • Animals
  • Brain-Derived Neurotrophic Factor
  • COS Cells
  • Cercopithecus aethiops
  • Dose-Response Relationship, Radiation
  • Electric Stimulation
  • Enzyme-Linked Immunosorbent Assay
  • Hippocampus
  • Immunoprecipitation
  • Long-Term Potentiation
  • Methionine
  • Mice
  • Mice, Knockout
  • Neurons
  • Patch-Clamp Techniques
  • Protein Precursors
  • Synaptic Transmission
  • Transfection
  • Tritium