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Lhx2 selector activity specifies cortical identity and suppresses hippocampal organizer fate.

Science (New York, N.Y.) | Jan 18, 2008

The earliest step in creating the cerebral cortex is the specification of neuroepithelium to a cortical fate. Using mouse genetic mosaics and timed inactivations, we demonstrated that Lhx2 acts as a classic selector gene and essential intrinsic determinant of cortical identity. Lhx2 selector activity is restricted to an early critical period when stem cells comprise the cortical neuroepithelium, where it acts cell-autonomously to specify cortical identity and suppress alternative fates in a spatially dependent manner. Laterally, Lhx2 null cells adopt antihem identity, whereas medially they become cortical hem cells, which can induce and organize ectopic hippocampal fields. In addition to providing functional evidence for Lhx2 selector activity, these findings show that the cortical hem is a hippocampal organizer.

Pubmed ID: 18202285 RIS Download

Mesh terms: Animals | Cell Aggregation | Cerebral Cortex | Chimera | Dentate Gyrus | Embryonic Induction | Embryonic Stem Cells | Epithelium | Gene Expression Regulation, Developmental | Hippocampus | Homeodomain Proteins | LIM-Homeodomain Proteins | Mice | Mice, Knockout | Mutation | Neuroepithelial Cells | Organizers, Embryonic | Prosencephalon | Pyramidal Cells | Recombination, Genetic | Telencephalon | Transcription Factors

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Associated grants

  • Agency: NIA NIH HHS, Id: K01 AG023583
  • Agency: NINDS NIH HHS, Id: NS053511
  • Agency: NIMH NIH HHS, Id: MH02029
  • Agency: NINDS NIH HHS, Id: T32 NS007444
  • Agency: NINDS NIH HHS, Id: NS07444
  • Agency: NIA NIH HHS, Id: AG23583
  • Agency: Wellcome Trust, Id: 056684/Z/99/Z
  • Agency: NIMH NIH HHS, Id: K08 MH002029

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