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Increased volume of the amygdala and hippocampus in bipolar patients treated with lithium.

Previous structural neuroimaging studies of bipolar disorder have reported conflicting findings in limbic structures. Medication heterogeneity of patient samples may have contributed to these inconsistencies. Using structural magnetic resonance imaging we assessed whether lithium treatment was associated with differences in amygdala and hippocampal volumes in a sample of bipolar adults. A total of 49 magnetic resonance imaging scans were collected from patients who were currently treated with or without lithium. Amygdala and hippocampal volumes were analyzed using tensor-based morphometry. Statistical between-group comparisons of deformation maps showed that patients treated with lithium exhibited significantly increased volumes of the amygdala and hippocampus compared with patients who were not taking lithium. Our findings may help to explain previous inconsistencies in the bipolar literature.

Pubmed ID: 18185112

Authors

  • Foland LC
  • Altshuler LL
  • Sugar CA
  • Lee AD
  • Leow AD
  • Townsend J
  • Narr KL
  • Asuncion DM
  • Toga AW
  • Thompson PM

Journal

Neuroreport

Publication Data

January 22, 2008

Associated Grants

  • Agency: NIBIB NIH HHS, Id: EB01651
  • Agency: NIMH NIH HHS, Id: F31 MH078556
  • Agency: NIMH NIH HHS, Id: F31 MH078556-03
  • Agency: NICHD NIH HHS, Id: HD050735
  • Agency: NIMH NIH HHS, Id: K24 MH001848
  • Agency: NIMH NIH HHS, Id: K24 MH001848-08
  • Agency: NIMH NIH HHS, Id: K24 MH001848-10
  • Agency: NIMH NIH HHS, Id: MH01848
  • Agency: NIMH NIH HHS, Id: MH078556
  • Agency: NICHD NIH HHS, Id: R01 HD050735
  • Agency: NICHD NIH HHS, Id: R01 HD050735-05
  • Agency: NCRR NIH HHS, Id: R21 RR019771
  • Agency: NCRR NIH HHS, Id: R21 RR019771-02
  • Agency: NCRR NIH HHS, Id: RR019771
  • Agency: NIEHS NIH HHS, Id: U13 ES016515-01

Mesh Terms

  • Adult
  • Amygdala
  • Antimanic Agents
  • Atrophy
  • Bipolar Disorder
  • Brain Mapping
  • Causality
  • Data Interpretation, Statistical
  • Female
  • Functional Laterality
  • Hippocampus
  • Humans
  • Image Processing, Computer-Assisted
  • Lithium Compounds
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Reproducibility of Results
  • Treatment Outcome