Maintenance has been completed and SciCrunch services have been restored. We apologize for any inconvenience it may have caused.

Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

COUP-TFI coordinates cortical patterning, neurogenesis, and laminar fate and modulates MAPK/ERK, AKT, and beta-catenin signaling.

A major unsolved question in cortical development is how proliferation, neurogenesis, regional growth, regional identity, and laminar fate specification are coordinated. Here we provide evidence, using loss-of-function and gain-of-function manipulations, that the COUP-TFI orphan nuclear receptor promotes ventral cortical fate, promotes cell cycle exit and neural differentiation, regulates the balance of early- and late-born neurons, and regulates the balanced production of different types of layer V cortical projection neurons. We suggest that COUP-TFI controls these processes by repressing Mapk/Erk, Akt, and beta-catenin signaling.

Pubmed ID: 18165280

Authors

  • Faedo A
  • Tomassy GS
  • Ruan Y
  • Teichmann H
  • Krauss S
  • Pleasure SJ
  • Tsai SY
  • Tsai MJ
  • Studer M
  • Rubenstein JL

Journal

Cerebral cortex (New York, N.Y. : 1991)

Publication Data

September 18, 2008

Associated Grants

  • Agency: NIMH NIH HHS, Id: K05 MH065670
  • Agency: NINDS NIH HHS, Id: NS34661
  • Agency: Telethon, Id: TGM06A04
  • Agency: Telethon, Id: TGM06S01

Mesh Terms

  • Animals
  • COUP Transcription Factor I
  • Cell Division
  • Extracellular Signal-Regulated MAP Kinases
  • Female
  • MAP Kinase Signaling System
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Mitogen-Activated Protein Kinases
  • Neocortex
  • Neurons
  • Phosphatidylinositol 3-Kinases
  • Proto-Oncogene Proteins c-akt
  • Stem Cells
  • beta Catenin