Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

COUP-TFI coordinates cortical patterning, neurogenesis, and laminar fate and modulates MAPK/ERK, AKT, and beta-catenin signaling.

http://www.ncbi.nlm.nih.gov/pubmed/18165280

A major unsolved question in cortical development is how proliferation, neurogenesis, regional growth, regional identity, and laminar fate specification are coordinated. Here we provide evidence, using loss-of-function and gain-of-function manipulations, that the COUP-TFI orphan nuclear receptor promotes ventral cortical fate, promotes cell cycle exit and neural differentiation, regulates the balance of early- and late-born neurons, and regulates the balanced production of different types of layer V cortical projection neurons. We suggest that COUP-TFI controls these processes by repressing Mapk/Erk, Akt, and beta-catenin signaling.

Pubmed ID: 18165280 RIS Download

Mesh terms: Animals | COUP Transcription Factor I | Cell Division | Extracellular Signal-Regulated MAP Kinases | Female | MAP Kinase Signaling System | Male | Mice | Mice, Inbred BALB C | Mice, Inbred C57BL | Mice, Transgenic | Mitogen-Activated Protein Kinases | Neocortex | Neurons | Phosphatidylinositol 3-Kinases | Proto-Oncogene Proteins c-akt | Stem Cells | beta Catenin

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.