Multiple kinases and system robustness: a link between Cdc37 and genome integrity.
We identified 38 genes as having a genetic interaction with a mutant form of the kinase specific chaperone, Cdc37, using a genome-wide synthetic screening approach. The identified genes included a sub-network of highly interacting genes enriched for functions in genome integrity and comprising multiple components of several discrete molecular machines. A network analysis approach related these machines to a small group of cell cycle checkpoint kinases.
Pubmed ID: 18075309 RIS Download
Cell Cycle Proteins | Genomic Instability | Molecular Chaperones | Mutation | Phosphotransferases | Saccharomyces cerevisiae Proteins