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Multiple kinases and system robustness: a link between Cdc37 and genome integrity.

We identified 38 genes as having a genetic interaction with a mutant form of the kinase specific chaperone, Cdc37, using a genome-wide synthetic screening approach. The identified genes included a sub-network of highly interacting genes enriched for functions in genome integrity and comprising multiple components of several discrete molecular machines. A network analysis approach related these machines to a small group of cell cycle checkpoint kinases.

Pubmed ID: 18075309

Authors

  • Caplan AJ
  • Ma'ayan A
  • Willis IM

Journal

Cell cycle (Georgetown, Tex.)

Publication Data

December 15, 2007

Associated Grants

  • Agency: NIGMS NIH HHS, Id: GM42728
  • Agency: NIGMS NIH HHS, Id: GM54508
  • Agency: NIGMS NIH HHS, Id: GM70596
  • Agency: NIGMS NIH HHS, Id: P50 GM071558
  • Agency: NIGMS NIH HHS, Id: P50 GM071558-01A20007
  • Agency: NIGMS NIH HHS, Id: P50 GM071558-020007
  • Agency: NIGMS NIH HHS, Id: P50 GM071558-030007
  • Agency: NIDDK NIH HHS, Id: R01 DK049065-04
  • Agency: NIGMS NIH HHS, Id: R01 GM060631
  • Agency: NIGMS NIH HHS, Id: R01 GM060631-01A1
  • Agency: NIGMS NIH HHS, Id: R01 GM060631-02
  • Agency: NIGMS NIH HHS, Id: R01 GM060631-03
  • Agency: NIGMS NIH HHS, Id: R01 GM060631-04
  • Agency: NIGMS NIH HHS, Id: R01 GM070596-01A1
  • Agency: NIGMS NIH HHS, Id: R01 GM070596-02
  • Agency: NIGMS NIH HHS, Id: R01 GM070596-03
  • Agency: NIGMS NIH HHS, Id: R01 GM070596-04
  • Agency: NIGMS NIH HHS, Id: R01 GM070596-04S2

Mesh Terms

  • Cell Cycle Proteins
  • Genomic Instability
  • Molecular Chaperones
  • Mutation
  • Phosphotransferases
  • Saccharomyces cerevisiae Proteins