Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex.

Cancer cell | Dec 10, 2007

To better understand the cellular origin of breast cancer, we developed a mouse model that recapitulates expression of the ETV6-NTRK3 (EN) fusion oncoprotein, the product of the t(12;15)(p13;q25) translocation characteristic of human secretory breast carcinoma. Activation of EN expression in mammary tissues by Wap-Cre leads to fully penetrant, multifocal malignant breast cancer with short latency. We provide genetic evidence that, in nulliparous Wap-Cre;EN females, committed alveolar bipotent or CD61(+) luminal progenitors are targets of tumorigenesis. Furthermore, EN transforms these otherwise transient progenitors through activation of the AP1 complex. Given the increasing relevance of chromosomal translocations in epithelial cancers, such mice serve as a paradigm for the study of their genetic pathogenesis and cellular origins, and generation of preclinical models.

Pubmed ID: 18068631 RIS Download

Mesh terms: Alleles | Animals | Antigens, CD24 | Breast Neoplasms | Cell Transformation, Neoplastic | Epithelial Cells | Female | Genes, Dominant | Humans | Integrases | Mammary Glands, Animal | Mammary Neoplasms, Animal | Mice | Multigene Family | Neoplastic Stem Cells | Oncogene Proteins, Fusion | Parity | Penetrance | Pregnancy | Proto-Oncogene Proteins c-ets | Proto-Oncogene Proteins c-jun | Repressor Proteins | Transcription Factor AP-1

Research resources used in this publication

None found

Research tools detected in this publication

Data used in this publication

Associated grants

  • Agency: NCI NIH HHS, Id: U01 CA105423-03
  • Agency: NCI NIH HHS, Id: U01 CA105423
  • Agency: NCI NIH HHS, Id: R01 CA101227
  • Agency: NCI NIH HHS, Id: N01CN43308
  • Agency: NCI NIH HHS, Id: N01-CN43308
  • Agency: NCI NIH HHS, Id: R01-CA-101227
  • Agency: NCI NIH HHS, Id: U01 CA105423-04

Mouse Genome Informatics (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

This is a list of tools and resources that we have found mentioned in this publication.


Gene Set Enrichment Analysis

Software package for interpreting gene expression data. Used for interpretation of a large-scale experiment by identifying pathways and processes.

tool

View all literature mentions

dChip Software

Software for analysis and visualization of gene expression and SNP microarrays.

tool

View all literature mentions