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The universal protein resource (UniProt).

Nucleic acids research | Jan 15, 2008

The Universal Protein Resource (UniProt) provides a stable, comprehensive, freely accessible, central resource on protein sequences and functional annotation. The UniProt Consortium is a collaboration between the European Bioinformatics Institute (EBI), the Protein Information Resource (PIR) and the Swiss Institute of Bioinformatics (SIB). The core activities include manual curation of protein sequences assisted by computational analysis, sequence archiving, development of a user-friendly UniProt website, and the provision of additional value-added information through cross-references to other databases. UniProt is comprised of four major components, each optimized for different uses: the UniProt Knowledgebase, the UniProt Reference Clusters, the UniProt Archive and the UniProt Metagenomic and Environmental Sequences database. UniProt is updated and distributed every three weeks, and can be accessed online for searches or download at http://www.uniprot.org.

Pubmed ID: 18045787 RIS Download

Mesh terms: Databases, Protein | Genomics | Internet | Proteins | Sequence Analysis, Protein | Systems Integration | User-Computer Interface | Viral Proteins

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Associated grants

  • Agency: NIGMS NIH HHS, Id: R01 GM080646
  • Agency: NIAID NIH HHS, Id: N01-AI-40035
  • Agency: NIAID NIH HHS, Id: HHSN266200400061C
  • Agency: NHGRI NIH HHS, Id: U01 HG002712
  • Agency: NIAID NIH HHS, Id: N01AI40035
  • Agency: NHGRI NIH HHS, Id: 2 U01 HG02712-05
  • Agency: NIGMS NIH HHS, Id: 1R01GM080646-01
  • Agency: NHGRI NIH HHS, Id: P41 HG002273

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A bioinformatics resource portal which provides access to scientific databases and software tools (i.e., resources) in different areas of life sciences including proteomics, genomics, structural bioinformatics, systems biology, phylogeny, evolution, population genetics, transcriptomics, biophysics, imaging, IT infrastructure, and drug design. On this portal users can find resources from many different SIB groups as well as external institutions.


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