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Cystatin C modulates cerebral beta-amyloidosis.

Nature genetics | Dec 29, 2007

http://www.ncbi.nlm.nih.gov/pubmed/18026102

The CST3 Thr25 allele of CST3, which encodes cystatin C, leads to reduced cystatin C secretion and conveys susceptibility to Alzheimer's disease. Here we show that overexpression of human cystatin C in brains of APP-transgenic mice reduces cerebral amyloid-beta deposition and that cystatin C binds amyloid-beta and inhibits its fibril formation. Our results suggest that cystatin C concentrations modulate cerebral amyloidosis risk and provide an opportunity for genetic risk assessment and therapeutic interventions.

Pubmed ID: 18026102 RIS Download

Mesh terms: Alzheimer Disease | Amino Acid Substitution | Amyloid beta-Protein Precursor | Amyloidosis | Animals | Brain | Cerebrum | Cystatin C | Cystatins | Humans | Mice | Mice, Transgenic | Point Mutation

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