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Leptin replacement alters brain response to food cues in genetically leptin-deficient adults.

A missense mutation in the ob gene causes leptin deficiency and morbid obesity. Leptin replacement to three adults with this mutation normalized body weight and eating behavior. Because the neural circuits mediating these changes were unknown, we paired functional magnetic resonance imaging (fMRI) with presentation of food cues to these subjects. During viewing of food-related stimuli, leptin replacement reduced brain activation in regions linked to hunger (insula, parietal and temporal cortex) while enhancing activation in regions linked to inhibition and satiety (prefrontal cortex). Leptin appears to modulate feeding behavior through these circuits, suggesting therapeutic targets for human obesity.

Pubmed ID: 17986612 RIS Download

Mesh terms: Brain | Feeding Behavior | Humans | Leptin | Magnetic Resonance Imaging

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Associated grants

  • Agency: NIGMS NIH HHS, Id: GM08042
  • Agency: NIDA NIH HHS, Id: R01 DA020726
  • Agency: NCRR NIH HHS, Id: RR00865
  • Agency: NIGMS NIH HHS, Id: T32 GM008042
  • Agency: NIDDK NIH HHS, Id: R01 DK063240
  • Agency: NCRR NIH HHS, Id: RR016996
  • Agency: NCRR NIH HHS, Id: M01 RR000865
  • Agency: NIDA NIH HHS, Id: P20 DA022539
  • Agency: NIDDK NIH HHS, Id: DK063240
  • Agency: NIDA NIH HHS, Id: DA020726
  • Agency: NIGMS NIH HHS, Id: GM061394
  • Agency: NCRR NIH HHS, Id: RR017365
  • Agency: NIDA NIH HHS, Id: DA021961
  • Agency: NIGMS NIH HHS, Id: U01 GM061394
  • Agency: NCRR NIH HHS, Id: K24 RR016996
  • Agency: NIDDK NIH HHS, Id: R01 DK058851
  • Agency: NCRR NIH HHS, Id: K24 RR017365
  • Agency: NIDDK NIH HHS, Id: DK058851
  • Agency: NIDA NIH HHS, Id: DA022539
  • Agency: NIDA NIH HHS, Id: F30 DA021961

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