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Leptin replacement alters brain response to food cues in genetically leptin-deficient adults.

A missense mutation in the ob gene causes leptin deficiency and morbid obesity. Leptin replacement to three adults with this mutation normalized body weight and eating behavior. Because the neural circuits mediating these changes were unknown, we paired functional magnetic resonance imaging (fMRI) with presentation of food cues to these subjects. During viewing of food-related stimuli, leptin replacement reduced brain activation in regions linked to hunger (insula, parietal and temporal cortex) while enhancing activation in regions linked to inhibition and satiety (prefrontal cortex). Leptin appears to modulate feeding behavior through these circuits, suggesting therapeutic targets for human obesity.

Pubmed ID: 17986612

Authors

  • Baicy K
  • London ED
  • Monterosso J
  • Wong ML
  • Delibasi T
  • Sharma A
  • Licinio J

Journal

Proceedings of the National Academy of Sciences of the United States of America

Publication Data

November 13, 2007

Associated Grants

  • Agency: NIDA NIH HHS, Id: DA020726
  • Agency: NIDA NIH HHS, Id: DA021961
  • Agency: NIDA NIH HHS, Id: DA022539
  • Agency: NIDDK NIH HHS, Id: DK058851
  • Agency: NIDDK NIH HHS, Id: DK063240
  • Agency: NIGMS NIH HHS, Id: GM061394
  • Agency: NIGMS NIH HHS, Id: GM08042
  • Agency: NCRR NIH HHS, Id: RR00865
  • Agency: NCRR NIH HHS, Id: RR016996
  • Agency: NCRR NIH HHS, Id: RR017365

Mesh Terms

  • Brain
  • Feeding Behavior
  • Humans
  • Leptin
  • Magnetic Resonance Imaging