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Gabrb3 gene deficient mice exhibit impaired social and exploratory behaviors, deficits in non-selective attention and hypoplasia of cerebellar vermal lobules: a potential model of autism spectrum disorder.

OBJECTIVE: GABA(A) receptors play an important regulatory role in the developmental events leading to the formation of complex neuronal networks and to the behaviors they govern. The primary aim of this study was to assess whether gabrb3 gene deficient (gabrb3(-/-)) mice exhibit abnormal social behavior, a core deficit associated with autism spectrum disorder. METHODS: Social and exploratory behaviors along with non-selective attention were assessed in gabrb3(-/-), littermates (gabrb3(+/+)) and progenitor strains, C57BL/6J and 129/SvJ. In addition, semi-quantitative assessments of the size of cerebellar vermal lobules were performed on gabrb3(+/+) and gabrb3(-/-) mice. RESULTS: Relative to controls, gabrb3(-/-) mice exhibited significant deficits in activities related to social behavior including sociability, social novelty and nesting. In addition, gabrb3(-/-) mice also exhibited differences in exploratory behavior compared to controls, as well as reductions in the frequency and duration of rearing episodes, suggested as being an index of non-selective attention. Gabrb3(-/-) mice also displayed significant hypoplasia of the cerebellar vermis compared to gabrb3(+/+) mice. CONCLUSIONS: The observed behavioral deficits, especially regarding social behaviors, strengthens the face validity of the gabrb3 gene deficient mouse as being a model of autism spectrum disorder.

Pubmed ID: 17983671

Authors

  • DeLorey TM
  • Sahbaie P
  • Hashemi E
  • Homanics GE
  • Clark JD

Journal

Behavioural brain research

Publication Data

March 5, 2008

Associated Grants

  • Agency: NIAAA NIH HHS, Id: AA10422
  • Agency: NIMH NIH HHS, Id: MH065393
  • Agency: NIMH NIH HHS, Id: R01 MH065393-01A2
  • Agency: NIMH NIH HHS, Id: R01 MH065393-02
  • Agency: NIMH NIH HHS, Id: R01 MH065393-03
  • Agency: NIMH NIH HHS, Id: R01 MH065393-04

Mesh Terms

  • Analysis of Variance
  • Animals
  • Attention
  • Autistic Disorder
  • Cerebellar Cortex
  • Disease Models, Animal
  • Exploratory Behavior
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Nesting Behavior
  • Organ Size
  • Receptors, GABA-A
  • Social Behavior