• Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

The Chlamydomonas genome reveals the evolution of key animal and plant functions.

Chlamydomonas reinhardtii is a unicellular green alga whose lineage diverged from land plants over 1 billion years ago. It is a model system for studying chloroplast-based photosynthesis, as well as the structure, assembly, and function of eukaryotic flagella (cilia), which were inherited from the common ancestor of plants and animals, but lost in land plants. We sequenced the approximately 120-megabase nuclear genome of Chlamydomonas and performed comparative phylogenomic analyses, identifying genes encoding uncharacterized proteins that are likely associated with the function and biogenesis of chloroplasts or eukaryotic flagella. Analyses of the Chlamydomonas genome advance our understanding of the ancestral eukaryotic cell, reveal previously unknown genes associated with photosynthetic and flagellar functions, and establish links between ciliopathy and the composition and function of flagella.

Pubmed ID: 17932292

Authors

  • Merchant SS
  • Prochnik SE
  • Vallon O
  • Harris EH
  • Karpowicz SJ
  • Witman GB
  • Terry A
  • Salamov A
  • Fritz-Laylin LK
  • Maréchal-Drouard L
  • Marshall WF
  • Qu LH
  • Nelson DR
  • Sanderfoot AA
  • Spalding MH
  • Kapitonov VV
  • Ren Q
  • Ferris P
  • Lindquist E
  • Shapiro H
  • Lucas SM
  • Grimwood J
  • Schmutz J
  • Cardol P
  • Cerutti H
  • Chanfreau G
  • Chen CL
  • Cognat V
  • Croft MT
  • Dent R
  • Dutcher S
  • Fernández E
  • Fukuzawa H
  • González-Ballester D
  • González-Halphen D
  • Hallmann A
  • Hanikenne M
  • Hippler M
  • Inwood W
  • Jabbari K
  • Kalanon M
  • Kuras R
  • Lefebvre PA
  • Lemaire SD
  • Lobanov AV
  • Lohr M
  • Manuell A
  • Meier I
  • Mets L
  • Mittag M
  • Mittelmeier T
  • Moroney JV
  • Moseley J
  • Napoli C
  • Nedelcu AM
  • Niyogi K
  • Novoselov SV
  • Paulsen IT
  • Pazour G
  • Purton S
  • Ral JP
  • Riaño-Pachón DM
  • Riekhof W
  • Rymarquis L
  • Schroda M
  • Stern D
  • Umen J
  • Willows R
  • Wilson N
  • Zimmer SL
  • Allmer J
  • Balk J
  • Bisova K
  • Chen CJ
  • Elias M
  • Gendler K
  • Hauser C
  • Lamb MR
  • Ledford H
  • Long JC
  • Minagawa J
  • Page MD
  • Pan J
  • Pootakham W
  • Roje S
  • Rose A
  • Stahlberg E
  • Terauchi AM
  • Yang P
  • Ball S
  • Bowler C
  • Dieckmann CL
  • Gladyshev VN
  • Green P
  • Jorgensen R
  • Mayfield S
  • Mueller-Roeber B
  • Rajamani S
  • Sayre RT
  • Brokstein P
  • Dubchak I
  • Goodstein D
  • Hornick L
  • Huang YW
  • Jhaveri J
  • Luo Y
  • Martínez D
  • Ngau WC
  • Otillar B
  • Poliakov A
  • Porter A
  • Szajkowski L
  • Werner G
  • Zhou K
  • Grigoriev IV
  • Rokhsar DS
  • Grossman AR

Journal

Science (New York, N.Y.)

Publication Data

October 12, 2007

Associated Grants

  • Agency: NIGMS NIH HHS, Id: GM07185
  • Agency: NIGMS NIH HHS, Id: GM42143
  • Agency: NIGMS NIH HHS, Id: R01 GM032843
  • Agency: NIGMS NIH HHS, Id: R01 GM042143
  • Agency: NIGMS NIH HHS, Id: R01 GM042143-09
  • Agency: NIGMS NIH HHS, Id: R01 GM060992
  • Agency: NIGMS NIH HHS, Id: R01 GM062915-06
  • Agency: NIGMS NIH HHS, Id: R37 GM030626
  • Agency: NIGMS NIH HHS, Id: R37 GM042143

Mesh Terms

  • Algal Proteins
  • Animals
  • Biological Evolution
  • Chlamydomonas reinhardtii
  • Chloroplasts
  • Computational Biology
  • DNA, Algal
  • Flagella
  • Genes
  • Genome
  • Genomics
  • Membrane Transport Proteins
  • Molecular Sequence Data
  • Multigene Family
  • Photosynthesis
  • Phylogeny
  • Plants
  • Proteome
  • Sequence Analysis, DNA