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MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb.

MiR-150 is a microRNA (miRNA) specifically expressed in mature lymphocytes, but not their progenitors. A top predicted target of miR-150 is c-Myb, a transcription factor controlling multiple steps of lymphocyte development. Combining loss- and gain-of-function gene targeting approaches for miR-150 with conditional and partial ablation of c-Myb, we show that miR-150 indeed controls c-Myb expression in vivo in a dose-dependent manner over a narrow range of miRNA and c-Myb concentrations and that this dramatically affects lymphocyte development and response. Our results identify a key transcription factor as a critical target of a stage-specifically expressed miRNA in lymphocytes and suggest that this and perhaps other miRNAs have evolved to control the expression of just a few critical target proteins in particular cellular contexts.

Pubmed ID: 17923094


  • Xiao C
  • Calado DP
  • Galler G
  • Thai TH
  • Patterson HC
  • Wang J
  • Rajewsky N
  • Bender TP
  • Rajewsky K



Publication Data

October 5, 2007

Associated Grants

  • Agency: NIAID NIH HHS, Id: AI054636
  • Agency: NIAID NIH HHS, Id: AI059294
  • Agency: NIAID NIH HHS, Id: AI064345
  • Agency: NCI NIH HHS, Id: CA85842
  • Agency: NIAID NIH HHS, Id: R01 AI059294
  • Agency: NCI NIH HHS, Id: R01 CA085842

Mesh Terms

  • 3' Untranslated Regions
  • Animals
  • B-Lymphocytes
  • Cell Death
  • Cell Differentiation
  • Cells, Cultured
  • Gene Expression Regulation
  • Gene Targeting
  • Genes, Reporter
  • Humans
  • Immune System
  • Mice
  • Mice, Knockout
  • MicroRNAs
  • Proto-Oncogene Proteins c-myb
  • T-Lymphocytes