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Protein-tyrosine phosphatase H1 controls growth hormone receptor signaling and systemic growth.

http://www.ncbi.nlm.nih.gov/pubmed/17921143

Several protein-tyrosine phosphatases (PTPs) have been implicated in the control of growth hormone receptor (GHR) signaling, but none have been shown to affect growth in vivo. We have applied a battery of molecular and cellular approaches to test a family-wide panel of PTPs for interference with GHR signaling. Among the subset of PTPs that showed activity in multiple readouts, we selected PTP-H1/PTPN3 for further in vivo studies and found that mice lacking the PTP-H1 catalytic domain show significantly enhanced growth over their wild type littermates. In addition, PTP-H1 mutant animals had enhanced plasma and liver mRNA expression of insulin-like growth factor 1, as well as increased bone density and mineral content. These observations point to a controlling role for PTP-H1 in modulating GHR signaling and systemic growth through insulin-like growth factor 1 secretion.

Pubmed ID: 17921143 RIS Download

Mesh terms: Animals | Catalytic Domain | Cell Proliferation | Female | Humans | Insulin-Like Growth Factor I | Liver | Male | Mice | Mice, Knockout | Models, Biological | Mutation | Phosphorylation | Protein Tyrosine Phosphatase, Non-Receptor Type 3 | RNA, Messenger | Receptors, Somatotropin | Signal Transduction

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