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Mesenchymal stem cells within tumour stroma promote breast cancer metastasis.

Mesenchymal stem cells have been recently described to localize to breast carcinomas, where they integrate into the tumour-associated stroma. However, the involvement of mesenchymal stem cells (or their derivatives) in tumour pathophysiology has not been addressed. Here, we demonstrate that bone-marrow-derived human mesenchymal stem cells, when mixed with otherwise weakly metastatic human breast carcinoma cells, cause the cancer cells to increase their metastatic potency greatly when this cell mixture is introduced into a subcutaneous site and allowed to form a tumour xenograft. The breast cancer cells stimulate de novo secretion of the chemokine CCL5 (also called RANTES) from mesenchymal stem cells, which then acts in a paracrine fashion on the cancer cells to enhance their motility, invasion and metastasis. This enhanced metastatic ability is reversible and is dependent on CCL5 signalling through the chemokine receptor CCR5. Collectively, these data demonstrate that the tumour microenvironment facilitates metastatic spread by eliciting reversible changes in the phenotype of cancer cells.

Pubmed ID: 17914389


  • Karnoub AE
  • Dash AB
  • Vo AP
  • Sullivan A
  • Brooks MW
  • Bell GW
  • Richardson AL
  • Polyak K
  • Tubo R
  • Weinberg RA



Publication Data

October 4, 2007

Associated Grants

  • Agency: NCI NIH HHS, Id: P50 CA089393
  • Agency: NCI NIH HHS, Id: P50 CA089393-060014
  • Agency: NCI NIH HHS, Id: P50 CA089393-070014
  • Agency: NCI NIH HHS, Id: P50 CA089393-080014
  • Agency: NCI NIH HHS, Id: R01 CA116235
  • Agency: NCI NIH HHS, Id: R01 CA116235-01A1
  • Agency: NCI NIH HHS, Id: R01 CA116235-02
  • Agency: NCI NIH HHS, Id: R01 CA116235-03

Mesh Terms

  • Animals
  • Breast Neoplasms
  • Carcinoma, Ductal, Breast
  • Cell Line, Tumor
  • Cell Movement
  • Chemokine CCL5
  • Chemokines, CC
  • Fibroblasts
  • Humans
  • Lung Neoplasms
  • Mesenchymal Stem Cell Transplantation
  • Mesenchymal Stromal Cells
  • Mice
  • Mice, Inbred NOD
  • Mice, SCID
  • Neoplasm Invasiveness
  • Neoplasm Metastasis
  • Neoplasm Transplantation
  • Paracrine Communication
  • Receptors, CCR5
  • Stromal Cells