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A global analysis of genetic interactions in Caenorhabditis elegans.

Journal of biology | 2007

Understanding gene function and genetic relationships is fundamental to our efforts to better understand biological systems. Previous studies systematically describing genetic interactions on a global scale have either focused on core biological processes in protozoans or surveyed catastrophic interactions in metazoans. Here, we describe a reliable high-throughput approach capable of revealing both weak and strong genetic interactions in the nematode Caenorhabditis elegans.

Pubmed ID: 17897480 RIS Download

Research resources used in this publication

None found

Antibodies used in this publication

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Associated grants

  • Agency: NIGMS NIH HHS, United States
    Id: T32 GM070386
  • Agency: NIGMS NIH HHS, United States
    Id: 1 T32 GM070386-01
  • Agency: Canadian Institutes of Health Research, Canada

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This is a list of tools and resources that we have found mentioned in this publication.


BioCarta Pathways (tool)

RRID:SCR_006917

BioCarta Pathways allows users to observe how genes interact in dynamic graphical models. Online maps available within this resource depict molecular relationships from areas of active research. In an open source approach, this community-fed forum constantly integrates emerging proteomic information from the scientific community. It also catalogs and summarizes important resources providing information for over 120,000 genes from multiple species. Find both classical pathways as well as current suggestions for new pathways.

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Cluster (tool)

RRID:SCR_013505

Software R package. Methods for Cluster analysis. Performs variety of types of cluster analysis and other types of processing on large microarray datasets.

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SP506 (tool)

RRID:WB-STRAIN:WBStrain00034250

Caenorhabditis elegans with name clk-2(mn159) III. from WB.

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UP604 (tool)

RRID:WB-STRAIN:WBStrain00035412

Caenorhabditis elegans with name sos-1(cs41) V. from WB.

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