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FKF1 and GIGANTEA complex formation is required for day-length measurement in Arabidopsis.

Science (New York, N.Y.) | Oct 12, 2007

http://www.ncbi.nlm.nih.gov/pubmed/17872410

Precise timing of CONSTANS (CO) gene expression is necessary for day-length discrimination for photoperiodic flowering. The FLAVIN-BINDING, KELCH REPEAT, F-BOX 1 (FKF1), and GIGANTEA (GI) proteins regulate CO transcription in Arabidopsis. We demonstrate that FKF1 and GI proteins form a complex in a blue-light-dependent manner. The timing of this interaction regulates the timing of daytime CO expression. FKF1 function is dependent on GI, which interacts with a CO repressor, CYCLING DOF FACTOR 1 (CDF1), and controls CDF1 stability. GI, FKF1, and CDF1 proteins associate with CO chromatin. Thus, the FKF1-GI complex forms on the CO promoter in late afternoon to regulate CO expression, providing a mechanistic view of how the coincidence of light with circadian timing regulates photoperiodic flowering.

Pubmed ID: 17872410 RIS Download

Mesh terms: Arabidopsis | Arabidopsis Proteins | Chromatin | Chromatin Immunoprecipitation | Circadian Rhythm | DNA-Binding Proteins | Flowers | Gene Expression Regulation, Plant | Light | Mutation | Photoperiod | Plants, Genetically Modified | Promoter Regions, Genetic | Protein Structure, Tertiary | Recombinant Fusion Proteins | Repressor Proteins | Transcription Factors

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Associated grants

  • Agency: NIGMS NIH HHS, Id: GM056006
  • Agency: NIGMS NIH HHS, Id: GM067837
  • Agency: NIGMS NIH HHS, Id: GM079712
  • Agency: NIGMS NIH HHS, Id: R01 GM079712
  • Agency: NIGMS NIH HHS, Id: R01 GM079712-03

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