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Open Access Series of Imaging Studies (OASIS): cross-sectional MRI data in young, middle aged, nondemented, and demented older adults.

The Open Access Series of Imaging Studies is a series of magnetic resonance imaging data sets that is publicly available for study and analysis. The initial data set consists of a cross-sectional collection of 416 subjects aged 18 to 96 years. One hundred of the included subjects older than 60 years have been clinically diagnosed with very mild to moderate Alzheimer's disease. The subjects are all right-handed and include both men and women. For each subject, three or four individual T1-weighted magnetic resonance imaging scans obtained in single imaging sessions are included. Multiple within-session acquisitions provide extremely high contrast-to-noise ratio, making the data amenable to a wide range of analytic approaches including automated computational analysis. Additionally, a reliability data set is included containing 20 subjects without dementia imaged on a subsequent visit within 90 days of their initial session. Automated calculation of whole-brain volume and estimated total intracranial volume are presented to demonstrate use of the data for measuring differences associated with normal aging and Alzheimer's disease.

Pubmed ID: 17714011


  • Marcus DS
  • Wang TH
  • Parker J
  • Csernansky JG
  • Morris JC
  • Buckner RL


Journal of cognitive neuroscience

Publication Data

September 23, 2007

Associated Grants

  • Agency: NIA NIH HHS, Id: P01 AG03991
  • Agency: NIMH NIH HHS, Id: P20 MH071616
  • Agency: NIA NIH HHS, Id: P50 AG05681
  • Agency: NIA NIH HHS, Id: R01 AG021910
  • Agency: NIA NIH HHS, Id: R01 AG021910-03
  • Agency: NIA NIH HHS, Id: R01 AG021910-04
  • Agency: NIBIB NIH HHS, Id: R01 EB009352
  • Agency: NCRR NIH HHS, Id: RR 16594
  • Agency: NCRR NIH HHS, Id: RR14075

Mesh Terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aging
  • Brain
  • Brain Mapping
  • Cross-Sectional Studies
  • Dementia
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Reproducibility of Results
  • Sex Factors