• Register
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.


Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.


A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation.

Deciphering the epigenetic "code" remains a central issue in transcriptional regulation. Here, we report the identification of a JAMM/MPN(+) domain-containing histone H2A deubiquitinase (2A-DUB, or KIAA1915/MYSM1) specific for monoubiquitinated H2A (uH2A) that has permitted delineation of a strategy for specific regulatory pathways of gene activation. 2A-DUB regulates transcription by coordinating histone acetylation and deubiquitination, and destabilizing the association of linker histone H1 with nucleosomes. 2A-DUB interacts with p/CAF in a coregulatory protein complex, with its deubiquitinase activity modulated by the status of acetylation of nucleosomal histones. Consistent with this mechanistic role, 2A-DUB participates in transcriptional regulation events in androgen receptor-dependent gene activation, and the levels of uH2A are dramatically decreased in prostate tumors, serving as a cancer-related mark. We suggest that H2A ubiquitination represents a widely used mechanism for many regulatory transcriptional programs and predict that various H2A ubiquitin ligases/deubiquitinases will be identified for specific cohorts of regulated transcription units.

Pubmed ID: 17707232


  • Zhu P
  • Zhou W
  • Wang J
  • Puc J
  • Ohgi KA
  • Erdjument-Bromage H
  • Tempst P
  • Glass CK
  • Rosenfeld MG


Molecular cell

Publication Data

August 17, 2007

Associated Grants

  • Agency: NHLBI NIH HHS, Id: R01 HL065445
  • Agency: NHLBI NIH HHS, Id: R01 HL065445-09
  • Agency: NINDS NIH HHS, Id: R01 NS048243
  • Agency: NINDS NIH HHS, Id: R01 NS048243-03
  • Agency: NIDDK NIH HHS, Id: R37 DK039949
  • Agency: NIDDK NIH HHS, Id: R37 DK039949-27

Mesh Terms

  • Acetylation
  • Androgens
  • Animals
  • Cell Line
  • Chromatography, Affinity
  • DNA-Binding Proteins
  • Gene Expression Regulation
  • Histone Acetyltransferases
  • Histones
  • Humans
  • Mice
  • Models, Genetic
  • Nucleosomes
  • Phosphorylation
  • Receptors, Androgen
  • Signal Transduction
  • Transcription Factors
  • Transcription, Genetic
  • Transcriptional Activation
  • Ubiquitins