Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Human genome ultraconserved elements are ultraselected.

Science (New York, N.Y.) | Aug 17, 2007

Ultraconserved elements in the human genome are defined as stretches of at least 200 base pairs of DNA that match identically with corresponding regions in the mouse and rat genomes. Most ultraconserved elements are noncoding and have been evolutionarily conserved since mammal and bird ancestors diverged over 300 million years ago. The reason for this extreme conservation remains a mystery. It has been speculated that they are mutational cold spots or regions where every site is under weak but still detectable negative selection. However, analysis of the derived allele frequency spectrum shows that these regions are in fact under negative selection that is much stronger than that in protein coding genes.

Pubmed ID: 17702936 RIS Download

Mesh terms: Bayes Theorem | Conserved Sequence | Gene Frequency | Genome, Human | Humans | Likelihood Functions | Polymorphism, Single Nucleotide | Selection, Genetic