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Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans.

http://www.ncbi.nlm.nih.gov/pubmed/17675407

Here, we report generation and characterization of Disrupted-In-Schizophrenia-1 (DISC1) genetically engineered mice as a potential model for major mental illnesses, such as schizophrenia. DISC1 is a promising genetic risk factor for major mental illnesses. In this transgenic model, a dominant-negative form of DISC1 (DN-DISC1) is expressed under the alphaCaMKII promoter. In vivo MRI of the DN-DISC1 mice detected enlarged lateral ventricles particularly on the left side, suggesting a link to the asymmetrical change in anatomy found in brains of patients with schizophrenia. Furthermore, selective reduction in the immunoreactivity of parvalbumin in the cortex, a marker for an interneuron deficit that may underlie cortical asynchrony, is observed in the DN-DISC1 mice. These results suggest that these transgenic mice may be used as a model for schizophrenia. DN-DISC1 mice also display several behavioral abnormalities, including hyperactivity, disturbance in sensorimotor gating and olfactory-associated behavior, and an anhedonia/depression-like deficit.

Pubmed ID: 17675407 RIS Download

Mesh terms: Animals | Behavior, Animal | Biological Markers | Disease Models, Animal | Genes, Dominant | Humans | Mice | Mice, Transgenic | Nerve Tissue Proteins | Phenotype | Schizophrenia

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Associated grants

  • Agency: NIMH NIH HHS, Id: MH-069853
  • Agency: NIA NIH HHS, Id: P01-AG-017688

Mouse Genome Informatics (Data, Gene Annotation)

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