CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response.
The product of the breast cancer-1 gene, BRCA1, plays a crucial part in the DNA damage response through its interactions with many proteins, including BACH1, CtIP and RAP80. Here we identify a coiled-coil domain-containing protein, CCDC98, as a BRCA1-interacting protein. CCDC98 colocalizes with BRCA1 and is required for the formation of BRCA1 foci in response to ionizing radiation. Moreover, like BRCA1, CCDC98 has a role in radiation sensitivity and damage-induced G2/M checkpoint control. Together, these results suggest that CCDC98 is a mediator of BRCA1 function involved in the mammalian DNA damage response.
Pubmed ID: 17643122 RIS Download
Amino Acid Motifs | BRCA1 Protein | Carrier Proteins | Cell Cycle | Cell Line | DNA Damage | DNA Repair | Humans | Protein Interaction Mapping | Protein Structure, Tertiary | Signal Transduction