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CCDC98 targets BRCA1 to DNA damage sites.

Breast cancer-1 (BRCA1) participates in the DNA damage response. However, the mechanism by which BRCA1 is recruited to DNA damage sites remains elusive. Recently, we have demonstrated that a ubiquitin-binding protein, RAP80, is required for DNA damage-induced BRCA1 translocation. Here we identify another component, CCDC98, in the BRCA1-RAP80 complex. CCDC98 mediates BRCA1's association with RAP80. Moreover, CCDC98 controls both DNA damage-induced formation of BRCA1 foci and BRCA1-dependent G2/M checkpoint activation. Together, our results demonstrate that CCDC98 is a BRCA1 binding partner that mediates BRCA1 function in response to DNA damage.

Pubmed ID: 17643121

Authors

  • Liu Z
  • Wu J
  • Yu X

Journal

Nature structural & molecular biology

Publication Data

August 6, 2007

Associated Grants

None

Mesh Terms

  • BRCA1 Protein
  • Carrier Proteins
  • Cell Cycle
  • Cell Line
  • DNA Damage
  • DNA Repair
  • Humans
  • Nuclear Proteins
  • Protein Interaction Mapping
  • Protein Structure, Tertiary
  • Protein Transport
  • Signal Transduction