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CCDC98 targets BRCA1 to DNA damage sites.

Breast cancer-1 (BRCA1) participates in the DNA damage response. However, the mechanism by which BRCA1 is recruited to DNA damage sites remains elusive. Recently, we have demonstrated that a ubiquitin-binding protein, RAP80, is required for DNA damage-induced BRCA1 translocation. Here we identify another component, CCDC98, in the BRCA1-RAP80 complex. CCDC98 mediates BRCA1's association with RAP80. Moreover, CCDC98 controls both DNA damage-induced formation of BRCA1 foci and BRCA1-dependent G2/M checkpoint activation. Together, our results demonstrate that CCDC98 is a BRCA1 binding partner that mediates BRCA1 function in response to DNA damage.

Pubmed ID: 17643121 RIS Download

Mesh terms: BRCA1 Protein | Carrier Proteins | Cell Cycle | Cell Line | DNA Damage | DNA Repair | Humans | Nuclear Proteins | Protein Interaction Mapping | Protein Structure, Tertiary | Protein Transport | Signal Transduction

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