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A mammalian microRNA expression atlas based on small RNA library sequencing.

MicroRNAs (miRNAs) are small noncoding regulatory RNAs that reduce stability and/or translation of fully or partially sequence-complementary target mRNAs. In order to identify miRNAs and to assess their expression patterns, we sequenced over 250 small RNA libraries from 26 different organ systems and cell types of human and rodents that were enriched in neuronal as well as normal and malignant hematopoietic cells and tissues. We present expression profiles derived from clone count data and provide computational tools for their analysis. Unexpectedly, a relatively small set of miRNAs, many of which are ubiquitously expressed, account for most of the differences in miRNA profiles between cell lineages and tissues. This broad survey also provides detailed and accurate information about mature sequences, precursors, genome locations, maturation processes, inferred transcriptional units, and conservation patterns. We also propose a subclassification scheme for miRNAs for assisting future experimental and computational functional analyses.

Pubmed ID: 17604727


  • Landgraf P
  • Rusu M
  • Sheridan R
  • Sewer A
  • Iovino N
  • Aravin A
  • Pfeffer S
  • Rice A
  • Kamphorst AO
  • Landthaler M
  • Lin C
  • Socci ND
  • Hermida L
  • Fulci V
  • Chiaretti S
  • Foà R
  • Schliwka J
  • Fuchs U
  • Novosel A
  • Müller RU
  • Schermer B
  • Bissels U
  • Inman J
  • Phan Q
  • Chien M
  • Weir DB
  • Choksi R
  • De Vita G
  • Frezzetti D
  • Trompeter HI
  • Hornung V
  • Teng G
  • Hartmann G
  • Palkovits M
  • Di Lauro R
  • Wernet P
  • Macino G
  • Rogler CE
  • Nagle JW
  • Ju J
  • Papavasiliou FN
  • Benzing T
  • Lichter P
  • Tam W
  • Brownstein MJ
  • Bosio A
  • Borkhardt A
  • Russo JJ
  • Sander C
  • Zavolan M
  • Tuschl T



Publication Data

June 29, 2007

Associated Grants

  • Agency: NIGMS NIH HHS, Id: P01 GM073047
  • Agency: NIGMS NIH HHS, Id: P01 GM073047-01
  • Agency: NIGMS NIH HHS, Id: P01 GM073047-03

Mesh Terms

  • Animals
  • Base Sequence
  • Cell Lineage
  • Conserved Sequence
  • Gene Expression Profiling
  • Gene Expression Regulation
  • Gene Library
  • Hematologic Neoplasms
  • Hematopoietic Stem Cells
  • Humans
  • Mice
  • MicroRNAs
  • Molecular Sequence Data
  • Phylogeny
  • RNA, Messenger
  • Rats
  • Sequence Homology, Nucleic Acid