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Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity.

Cancer cell | Jun 11, 2007

AML1/ETO results from the t(8;21) associated with 12%-15% of acute myeloid leukemia. The AML1/ETO MYND domain mediates interactions with the corepressors SMRT and N-CoR and contributes to AML1/ETO's ability to repress proliferation and differentiation of primary bone marrow cells as well as to enhance their self renewal in vitro. We solved the solution structure of the MYND domain and show it to be structurally homologous to the PHD and RING finger families of proteins. We also determined the solution structure of an MYND-SMRT peptide complex. We demonstrated that a single amino acid substitution that disrupts the interaction between the MYND domain and the SMRT peptide attenuated AML1/ETO's effects on proliferation, differentiation, and gene expression.

Pubmed ID: 17560331 RIS Download

Mesh terms: Animals | Bone Marrow Cells | Cell Differentiation | Cell Line | Cell Proliferation | Core Binding Factor Alpha 2 Subunit | Gene Expression | Humans | Mice | Models, Molecular | Mutation | Nuclear Proteins | Nuclear Receptor Co-Repressor 1 | Oncogene Proteins, Fusion | Protein Binding | Protein Structure, Tertiary | Repressor Proteins

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Associated grants

  • Agency: NCI NIH HHS, Id: R01 CA108056-03
  • Agency: NIGMS NIH HHS, Id: T32 GM08704
  • Agency: NCI NIH HHS, Id: R01 CA108056
  • Agency: NCI NIH HHS, Id: R01 CA108056-04
  • Agency: NIAMS NIH HHS, Id: T32 AR07576
  • Agency: NCI NIH HHS, Id: R01 CA108056-01
  • Agency: NIGMS NIH HHS, Id: T32 GM008704
  • Agency: NIAMS NIH HHS, Id: T32 AR007576
  • Agency: NCI NIH HHS, Id: R01 CA108056-02

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