• Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

Imaging axonal transport of mitochondria in vivo.

Neuronal mitochondria regulate synaptic physiology and cellular survival, and disruption of their function or transport causes neurological disease. We present a fluorescence method to selectively image mitochondrial dynamics in the mouse nervous system, in both live mice and acute explants. We show that axon damage and recovery lead to early and sustained changes in anterograde and retrograde transport. In vivo imaging of mitochondria will be a useful tool to analyze this essential organelle.

Pubmed ID: 17558414

Authors

  • Misgeld T
  • Kerschensteiner M
  • Bareyre FM
  • Burgess RW
  • Lichtman JW

Journal

Nature methods

Publication Data

July 29, 2007

Associated Grants

None

Mesh Terms

  • Animals
  • Axonal Transport
  • Axons
  • Luminescent Proteins
  • Mice
  • Mitochondria
  • Neurons
  • Spectrometry, Fluorescence