Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

'Rejuvenation' protects neurons in mouse models of Parkinson's disease.

Nature | Jun 28, 2007

http://www.ncbi.nlm.nih.gov/pubmed/17558391

Why dopamine-containing neurons of the brain's substantia nigra pars compacta die in Parkinson's disease has been an enduring mystery. Our studies suggest that the unusual reliance of these neurons on L-type Ca(v)1.3 Ca2+ channels to drive their maintained, rhythmic pacemaking renders them vulnerable to stressors thought to contribute to disease progression. The reliance on these channels increases with age, as juvenile dopamine-containing neurons in the substantia nigra pars compacta use pacemaking mechanisms common to neurons not affected in Parkinson's disease. These mechanisms remain latent in adulthood, and blocking Ca(v)1.3 Ca2+ channels in adult neurons induces a reversion to the juvenile form of pacemaking. Such blocking ('rejuvenation') protects these neurons in both in vitro and in vivo models of Parkinson's disease, pointing to a new strategy that could slow or stop the progression of the disease.

Pubmed ID: 17558391 RIS Download

Mesh terms: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | Aging | Animals | Antiparkinson Agents | Calcium | Calcium Channels, L-Type | Dendrites | Disease Models, Animal | Disease Progression | Dopamine | Electric Conductivity | Gene Deletion | Male | Mice | Mice, Inbred C57BL | Mitochondria | Models, Neurological | Neurons | Parkinson Disease | Rotenone | Substantia Nigra

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

None

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.