Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network.

Science (New York, N.Y.) | Jul 6, 2007

Forming distinct representations of multiple contexts, places, and episodes is a crucial function of the hippocampus. The dentate gyrus subregion has been suggested to fulfill this role. We have tested this hypothesis by generating and analyzing a mouse strain that lacks the gene encoding the essential subunit of the N-methyl-d-aspartate (NMDA) receptor NR1, specifically in dentate gyrus granule cells. The mutant mice performed normally in contextual fear conditioning, but were impaired in the ability to distinguish two similar contexts. A significant reduction in the context-specific modulation of firing rate was observed in the CA3 pyramidal cells when the mutant mice were transferred from one context to another. These results provide evidence that NMDA receptors in the granule cells of the dentate gyrus play a crucial role in the process of pattern separation.

Pubmed ID: 17556551 RIS Download

Mesh terms: Animals | Behavior, Animal | Conditioning (Psychology) | Cues | Dentate Gyrus | Discrimination (Psychology) | Excitatory Postsynaptic Potentials | Fear | Hippocampus | Learning | Maze Learning | Memory | Mice | Mice, Knockout | Neuronal Plasticity | Pattern Recognition, Physiological | Perforant Pathway | Pyramidal Cells | Receptors, N-Methyl-D-Aspartate | Recombination, Genetic | Synaptic Transmission

Research resources used in this publication

None found

Research tools detected in this publication

None found

Data used in this publication

None found

Associated grants

  • Agency: Medical Research Council, Id: G0501146
  • Agency: NIMH NIH HHS, Id: MH62122
  • Agency: NIMH NIH HHS, Id: P50-MH58880

Mouse Genome Informatics (Data, Gene Annotation)

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

We have not found any resources mentioned in this publication.