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Preservation of proliferating pancreatic progenitor cells by Delta-Notch signaling in the embryonic chicken pancreas.

BMC developmental biology | 2007

Genetic studies have shown that formation of pancreatic endocrine cells in mice is dependent on the cell autonomous action of the bHLH transcription factor Neurogenin3 and that the extent and timing of endocrine differentiation is controlled by Notch signaling. To further understand the mechanism by which Notch exerts this function, we have investigated pancreatic endocrine development in chicken embryos.

Pubmed ID: 17555568 RIS Download

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Zeiss LSM 800 with Airyscan Microscope (tool)

RRID:SCR_015963

Compact confocal microscope with highly sensitive GaAsP detection and fast linear scanning. The airyscan system allows capture images with high sensitivity and superresolution compared with conventional confocal microscope.

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Mouse monoclonal antibody against Pax6 (NCBI Gene ID: 395943) (antibody)

RRID:AB_10014651

This monoclonal targets Pax6 (NCBI Gene ID: 395943)

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