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GeneTrail--advanced gene set enrichment analysis.

We present a comprehensive and efficient gene set analysis tool, called 'GeneTrail' that offers a rich functionality and is easy to use. Our web-based application facilitates the statistical evaluation of high-throughput genomic or proteomic data sets with respect to enrichment of functional categories. GeneTrail covers a wide variety of biological categories and pathways, among others KEGG, TRANSPATH, TRANSFAC, and GO. Our web server provides two common statistical approaches, 'Over-Representation Analysis' (ORA) comparing a reference set of genes to a test set, and 'Gene Set Enrichment Analysis' (GSEA) scoring sorted lists of genes. Besides other newly developed features, GeneTrail's statistics module includes a novel dynamic-programming algorithm that improves the P-value computation of GSEA methods considerably. GeneTrail is freely accessible at

Pubmed ID: 17526521


  • Backes C
  • Keller A
  • Kuentzer J
  • Kneissl B
  • Comtesse N
  • Elnakady YA
  • Müller R
  • Meese E
  • Lenhof HP


Nucleic acids research

Publication Data

July 16, 2007

Associated Grants


Mesh Terms

  • Animals
  • Computational Biology
  • Database Management Systems
  • Databases, Genetic
  • Gene Expression Regulation
  • Genes, Fungal
  • Genome
  • Genomics
  • Humans
  • Internet
  • Models, Genetic
  • Models, Statistical
  • Programming Languages
  • Proteomics
  • Software
  • User-Computer Interface