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Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF.

Science (New York, N.Y.) | May 11, 2007

Hematopoietic stem cells in the bone marrow give rise to lymphoid progenitors, which subsequently differentiate into B and T lymphocytes. Here we show that the proto-oncogene LRF plays an essential role in the B versus T lymphoid cell-fate decision. We demonstrate that LRF is key for instructing early lymphoid progenitors in mice to develop into B lineage cells by repressing T cell-instructive signals produced by the cell-fate signal protein, Notch. We propose a new model for lymphoid lineage commitment, in which LRF acts as a master regulator of the cell's determination of B versus T lineage.

Pubmed ID: 17495164 RIS Download

Mesh terms: Animals | B-Lymphocytes | Bone Marrow Cells | Cell Lineage | Cells, Cultured | DNA-Binding Proteins | Gene Deletion | Hematopoietic Stem Cells | Lymphopoiesis | Mice | Mice, Inbred C57BL | Mice, Knockout | Models, Biological | Proto-Oncogenes | Receptors, Notch | Signal Transduction | T-Lymphocytes | Thymus Gland | Transcription Factors

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Associated grants

  • Agency: NCI NIH HHS, Id: R01 CA102142
  • Agency: NCI NIH HHS, Id: R01 CA102142-06A1
  • Agency: NCI NIH HHS, Id: CA-102142

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